Discontinuation of drugs

Isoniazid Adults S mg/kg (300 mg) Children 1 0-1 S mg/kg (300 mg) Asymptomatic elevation of aminotransferases, clinical hepatitis, fatal hepatitis, peripheral neurotoxicity, CNS system effects, lupus-like syndrome, hypersensitivity, monoamine poisoning, diarrhea LFT monthly in patients who have preexisting liver disease or who develop abnormal liver function that does not require discontinuation of drug Dosage adjustments may be necessary in patients receiving anticonvulsants or warfarin... 

Phospholipidosis is an excessive intracellular accumulation of phospholipids and drug, which is normally reversible after discontinuation of drug treatment. Currently, it is thought that phospholipidosis alone is not toxic per se, but because some compounds cause concurrent phospholipidosis and organ toxicity, avoidance of the issue in drug discovery projects seems prudent [74]. Fortunately, there are clear links between phospholipidosis and physical properties, especially lipophilicity, basicity, and amphiphilicity [75] which allow for good prediction of the risk. 

Photosensitivity Amiodarone has induced photosensitization in about 10% of patients. During long-term treatment, a blue-gray discoloration of the exposed skin may occur some protection may be afforded by sun barrier creams or protective clothing. This is slowly and occasionally incompletely reversible on discontinuation of drug. 

Answer Because of sertraline s favorable side effect profile and no need for dietary restrictions, it probably should be chosen over the older agents (TCAs and MAOIs). She should be warned about nausea and possibly loose stools, anorgasmia, and insomnia before she begins therapy. It also should be explained that the medication will take at least 2 weeks to begin working and that a complete trial of the medication to assess its efficacy will take 4 to 6 weeks. Since this is her first episode of depression, she should take the medication for 6 to 12 months after her symptoms have remitted before considering discontinuation of drug therapy. 

The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs. Diarrhea may be severe enough to necessitate discontinuation of drug use. Other adverse GI reactions include nausea, vomiting,... 

Studies needed to assess place in therapy with other bisphosphonates Inhibition of bone loss in osteoporosis maypersist up to 2 yr afterb mo of treatment and discontinuation of drug... 

Most of the drugs used to treat hyperlipidemia are well tolerated. Some gastrointestinal distress (nausea, diarrhea) is common with most of the drugs, but these problems are usually minor and do not require the discontinuation of drug therapy. 

Recurrence of original symptoms can occur when drug is stopped. Withdrawal effects on abrupt discontinuation of drug. These include dizziness, confusion and dysphoria. 

The development of latanoprost-induced corneal dendritiform epitheliopathy has been reported. These lesions resemble those of herpes simplex virus epithelial keratitis, but, in contrast to herpes simplex virus disease, the pseudodendrites associated with latanoprost promptly disappear on discontinuation of drug therapy. Coincident with discontinuation of latanoprost, patients can be treated with preservative-free artificial tears with or without topical antibiotics. 

In heaves-affected horses, fluticasone propionate (2000 pg twice daily by Equine AeroMask) has been shown to reduce pulmonary neutrophilia, improve parameters of pulmonary function and reduce responsiveness to histamine challenge during an episode of airway obstruction (Viel 1999). In normal horses, fluticasone propionate reduces serum cortisol concentrations by 40% after 1 day of therapy and by 65% after 7 days. Serum cortisol concentrations return to pretreatment values within 1-2 days after the discontinuation of drug treatment. 

Decreased respiratory and cardiovascular function due to general anesthetics must be carefully monitored and appropriate actions taken when necessary. Given the short time of induction and recovery for general anesthetics, discontinuation of drug administration may quickly resolve the depressant effect. 

A new series of MAO inhibitors are selective for MAOA and cause reversible inhibition of the enzyme, thus leaving MAOB in the liver intact to detoxify dietary amines, and showing rapid recovery of enzyme aetivity after discontinuation of drug treatment. The only drug of this type so far available for human use is moclobemide (15). 

Careful observation of a patient s response to treatment is necessary to confirm efficacy, prevent, detect, or manage adverse effects, assess compliance, and determine the need for dosage adjustment or discontinuation of drug therapy. 

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