Dipyridamole Acetylsalicylic acid

European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 1996 143(1-2) 1-13. 

The elimination of acetylsalicylic acid follows first-order kinetics with the dipyridamole and aspirin combination and has a half-life of 0.33 hours. The half-life of salicylic acid is 1.71 hours. 

Diener HC, Cunha L, Forbes C et al. (1996). European secondary prevention study 2 dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. Journal of Neurology Science 143 1-13 European Atrial Fibrillation Trial Study Group (1993). Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet 342 1255-1262... 

RajA SM, Salter MC, Donaldson DR, Subba Rao R, Boyle RM, Partridge IB, Watson DA Acetylsalicylic acid and dipyridamole improve the early patency of aorto-coronary bypass grafts. A double-blitid, placd>o-controlled, randomized trial. J. Thor. Cardiovasc. Surg. 373,1985... 

Protopine was shown to exhibit an inhibitory action on blood platelet aggregation induced by collagen, arachidonic acid, and ADP in vitro. In addition, protopine demonstrated equal or superior inhibitory effects when compared with that of the standard drugs acetylsalicylic acid or dipyridamole [266]. 

Dipyridamole 2 A, /V,/V, jV -tetrakis-(2-hydroxyethyl)-4,8-dipipcridinopyrimido[5,4- f]-pyrimidine-2,6-diaminc R1 = R2 = piperidino is marketed as a coronary vasodilator. It is used primarily in clinical practice as an antiplatelet agent. Dipyridamole increases the coronary blood flow and was originally introduced as an antianginal agent.179,180 It is usually combined with acetylsalicylic acid for synergistic antiaggregatory purposes.180,181... 

Spell and Stewart (1994) used HPTLC to determine p-aminosalicylic acid and its major impurity, m-aminophenol, in bulk and pharmaceuticals with chloroform-ethyl acetate-acetic acid-methanol (46 29 21 4) mobile phase. Agababa et al. (1995) developed an HPTLC method for the determination of acetylsalicylic acid and the impurity salicylic acid in tablets. Argekar and Kunjir (1996) described a method for simultaneous determination of aspirin and dipyridamole in tablets by HPTLC. McLaughlin and Sherma (1996) described a method for determining salicylic acid in anti-acne pharmaceuticals involving separation on a preadsorbent HPTLC-silica gel plate with fluorescent phosphor compound detection was by fluorescence quenching and quantification was by densitometric scanning. Salicylic acid was detected and quantified on the plate at levels as low as 1 pg. 

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