Diphosphoric reactions with

The fatty acid free derivative, II, is usually optically active and strongly suggests that the two glycerophosphate residues have the same stereochemical configuration. Otherwise this derivative would have had a meso configuration (with no optical activity). The peroxidation of II will yield 2 mol of formaldehyde per mole of phosphorus together with a dialdehyde, III, which on reaction with dimethylhydrazine will yield glycerol-1,3-diphosphoric acid, IV. 

Phosphorylation. Chambers et al. found the reagent useful for the preparation of nucleoside diphosphoric acids (3, R —adenine, uracil, etc.). A nucleotide (I) is converted into the 5 -phosphoramidate (2) by reaction with ammonia and dicyclo-hexylcarbodiimide (DCC), and the amidate (2) is treated with dioxane diphosphate in o-chlorophenol (3 hrs..0 ). The diphosphoric acid (3) is precipitated with petroleum ether and purified as the ammonium salt. Yields are around 90%, whereas when 8.5% phosphoric add was used yields were in the order of 50-60%. However, anhydrous... 

The dehydration reaction (elimination of H2O) between phosphoric acid (H3PO4) and diphosphoric acid (H4P2O7) results in the molecule H5P3O10 or tripolyphosphoric acid. A further dehydration reaction with phosphoric acid results in the formation of H6P4O13 or tetrapolyphosphoric acid. 

Problem 15.33. Write an equation for the reaction of diphosphoric acid with NaOH. Ans. Each acidic is replaced by Na until all four have been replaced ... 

When diphosphorous tetriodide is brought into contact with glycerin, an energetic reaction ensues, allylic iodide being formed —... 

The reaction of a molten mixture of 3,4-dihydro-2//-pyrido[ 1,2-a] pyrimidin-2-one 675 and phosphorous acid with phosphorus trichloride, followed by treatment of the reaction mixture with 2 N aqueous hydrochloric acid, afforded 3,4-dihydropyridopyrimidine-2,2-diphosphoric acid 676 in 38% yield (91GEP3930130). Catalytic reduction of diphosphonic acid 676 in water over platinum dioxide gave hexahydropyrido[l,2-a]pyrimi-dine-2,2-diphosphonic acid 677. 

The diphosphoric tetrafluoride for this synthesis is best prepared18 by reaction of phosphorodifluoridic acid with an excess of phosphorus ) oxide. Extremely pure P203F4 is not required. It contains about 5 % of the starting material. The same procedure, but using 18.6 g. (0.1 mole) of diphosphoric tetrafluoride instead of the acid in the method given above, may be utilized to prepare POF2Cl. The purification step described above is not necessary in this synthesis.12 The yield is 23 g. (95 %). 

The preparation of macrocyclic ligands by a direct alkylation of metal-coordinated amines using a template effect is rare because the complexed amine is seldom a good nucleophile. The complexed anilines, on the other hand, can be deprotonated, which enhances the nucleophilicity of the nitrogen atom. Such a reaction of a complexed diphosphorous-containing bisaniline with a ditosylate ester gave the complexed macrocyclic ligand (method AC-1) (Ansell et al., 1985). 

DIPHOSPHORIC ACID, TETRAETHYL ESTER (107-49-3) CgHjcO Pj Reacts with water, forming phosphoric acid and flammable ethylene gas. Alkalis or elevated temperatures above 300°F/149°C can cause deconqjosition, forming flammable ethylene gas and toxic phosphoms oxides. Reaction... 

The reactions of PH3 with water vapor and other compounds at 20 to 80"C under the influence of electric discharges were studied in model investigations of the primitive atmosphere of the earth. Mixtures of PH3 and H2O yielded insoluble polyphosphanes (probably PnH +2 containing elemental phosphorus), H3PO2, H3PO3, and H3PO4. The mixture PH3/H2O/NH3 yielded as additional products diphosphoric, triphosphoric, and higher acids, and possibly polymeric derivatives of phosphinic acid. The system PH3/H2O/NH3/CH4 produced the compounds mentioned above and in addition aminoacids, ethanolamine, and unspecified amino-... 

A soln. of 4-chlorophenyl phosphate, triethylamine, and di-a-pyridyl carbonate in abs. acetonitrile kept overnight at 60°, the crude intermediate a-pyridyl phosphate treated with phenyl phosphate in pyridine, and the product isolated as the cyclohexylammonium salt after 6-8 hrs. at room temp. P -phenyl P2-4-chlorophenyl diphosphate. Y 88.4%. F. e. and reactions of -pyridyl phosphates s. W. Kampe, B. 98, 1038 (1965) nucleoside diphosphoric acids s. B. 98, 1045 from a-pyridone instead of di-a-pyridyl carbonate cf. B. 99, 593 (1966). 

Oxoacids may undergo condensation reactions to form dimers, trimers and polymers. The term condensation refers to the reaction of two or more molecules to form a larger molecule, with the elimination of a small molecule such as water. Thus, phosphoric acid, H3PO4, can self-condense to produce diphosphoric acid and triphosphoric acid ... 

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