Diphenylhydantoin indications

Phenytoin. Phenytoin sodium is sodium diphenylhydantoin [630-93-3] which is stmcturally related to the barbiturates. It was originally introduced as an anticonvulsant (18) (see Hypnotics, sedatives, and anticonvulsants) and later found to have antiarrhythmic properties (19), although not approved by the PDA for any arrhythmic indications. Phenytoin is effective in the treatment of ventricular arrhythmias associated with acute MI and with digitalis toxicity (20). It is not very effective in treatment of supraventricular arrhythmias (20). 

Synonyms diphenylhydantoin DPH phenytoin sodium Trade names Di-Hydran Dilantin (Pfizer) Diphenylan Epanutin Fenytoin Phenhydan Phenytek Pyoredol Zentropil Indications Grand mal seizures... 

More recently it has become apparent that genetic factors also affect phase 1, oxidation pathways. Early reports of the defective metabolism of diphenylhydantoin in three families and of the defective deethylation of phenacetin in certain members of one family indicated a possible genetic component in microsomal enzyme-mediated reactions. Both these cases resulted in enhanced toxicity. Thus, diphenylhydantoin, a commonly used anticonvulsant, normally undergoes aromatic hydroxylation and the corresponding phenolic metabolite is excreted as a glucuronide (figure 7,35). Deficient... 

Still, we find empirically that superior activity against partial seizures requires at least one phenyl ring for its hydrophobic region. Diphenylhydantoin would seem to indicate... 

---