1.6- Dioxaspiro decane reduction

Aluminum chloride, 45, 109 with lithium aluminum hydride, in reduction of l,4-dioxaspiro[4 5] decane 47, 37... 

Lithium aluminum hydride, with aluminum chloride, for reduction of 4-f-butylcydohexanone, 47,17 in reduction of 1,4-dioxaspiro[4.5J-decane, 47, 38... 

Aluminum amalgam in reduction of oximinomalononitrile, 48, 2 Aluminum chloride, 46, 109 in conversion of tetramethy 1-1,3-cyclobutanedione to dimethyl-ketene d-lactone dimer, 48, 72 with lithium aluminum hydride, in reduction of l,4-dioxaspiro[4.5 -decane, 47, 37... 

In the final stages of the total synthesis of okadaic acid by C.J. Forsyth et al., the central 1,6-dioxaspiro[4,5]decane ring system was introduced by the enantioselective reduction of the Cl6 carbonyl group using (S)-CBS/BH3, followed by acid-catalyzed spiroketalization. ... 

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