2- 2,2-dimethylpropanoate

P-D- Glucopyranose, 3,4,5-tris-0-(phenylmethyl)-, 1-(dibutyl phosphate) 2-(2,2- dimethylpropanoate) ... 

Seebach and coworkers have developed the rtmldple coupling reagent, 2-tiitro-2-propenyl 2,2-dimethylpropanoate fNPPi. The reaction of nitromethane v/ith formaldehyde gives 1,3-dihydroxy-2-nitropropane in 95% yield. Subsequent acyladon v/ith two eqidviilents of pivaloyl chloride and elimination of pivalic acid affords NPP. The reacdon may be run on a 40- to 200-g... 

Chemical Name 2,2-Dimethylpropanoic acid 4-[ 1-hydroxy-2-(methylamino)ethyl] -1,2-phenylene ester... 

Methyl 2,2-dimethylpropanoate fCH CCC CJh has two peaks in its ]H NMR spectrum. What are their approximate chemical shifts ... 

Look at the NMR spectrum of methyl 2,2-dimethylpropanoate in Figure 13.12. There are two peaks, corresponding to the two kinds of protons, but the peaks aren t the same size. The peak at 1.2 5, due to the (CH3)3C- protons, is larger than the peak at 3.7 8, due to the -OCH3 protons. 

Figure 13.12 The 1H NMR spectrum of methyl 2,2-dimethylpropanoate. Integrating the peaks in a "stair-step" manner shows that they have a 1 3 ratio, corresponding to the ratio of the numbers of protons (3.91 responsible for each peak.

Pentanoic acid 3-Methylbutanoic acid 2,2-Dimethylpropanoic acid... 

Methyl 2,2-dimethylpropanoate, H NMR spectrum of, 459 Methyl acetate, electrostatic potential map of, 791... 

The lithium enolates of cyclopentanone and cyclohexanone undergo addition-elimination to the 2,2-dimethylpropanoic acid ester of ( )-2-nitro-2-hepten-l-ol to give 2-(l-butyl-2-nitro-2-propenyl)cycloalkanones with modest diastereoselection. An analogous reaction of the enolate ion of cyclohexanone with the 2,2-dimethylpropanoic acid ester of (Z)-2-nitro-3-phenyl-2-propenol to give 2-(2-nitro-l-phenyl-2-propenyl)cyclohexanones was also reported. The relative configuration of these products was not however determined6. 

Butanoic acid, methyl ester Malonic acid, dimethyl ester 1,1-Dimethylpropanoic acid, 1,1-dimethylester... 

---