Dimethylimidazolium dimethylphosphate

Quite recently, to develop an optimized synthetic protocol for the alkylation of 1-alkylimidazole compounds with trimethylphosphate, the kinetics of the synthesis of 1,3-dimethylimidazolium dimethylphosphate were studied in detail [45], The synthesis of the phosphonium salts derived from the reaction of phosphines with acids, has not been widely discussed. In 1991, Whitesides synthesized tris(2-carboxyethyl)phos-phine hydrochloride [47], Since then, air sensitive phosphonium salts have also been synthesized by the reaction of phosphine with a solution of aqueous HBF4 ... 

A good example was brought by Moniruzzaman et al. which have used ionic liquid-in-oil (IL/o) microemulsions to enhance the topical and transdermal delivery of acyclovir (ACV). The microemulsion was composed by a blend of nonionic surfactants, namely polyoxyethylene sorbitan monooleate (Tween-80) and sorbitan laurate (Span-20), isopropyl myristate (IPM) as an oil phase, and IL [Cimim](CH30)2P02 (dimethylimidazolium dimethylphosphate) as a pseudophase. The solubility of ACV on the microemulsion system significatively increased in the presence of IL, which act as a drug reservoir during the process of delivery. Moreover the transdermal delivery was only achieved when the IL was present in the microemulsion mixture. 

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