Dimethylaminopropyl acrylamide

Figure 5-4. 2-Bromo-2-bromomethylglutaronitrile, 2,2-dibromo-3-nitrilo-propionamide, 1,2-dimethyl-5-nitro-1 H-imidazole, 4,4-dimethyl-2-oxazo-lidinone, dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide, or dimethylaminopropyl acrylamide, 5,5-dimethylhydantoin, dimethylurea.

AMPS, 2-acrylamide-2-methylpropane sulfonic acid Mass, styrene sulphonic acid sodium salt DMAPAA, N,N-dimethylaminopropyl acrylamide HA, hyaluronic acid... 

Cross-linked polymer gels that switch on and off the supply of drug or biomolecules in response to changes in temperature and/or pH have been developed [36-41], An electrically controlled DDS has also been developed. For example, insulin was entrapped in a poly(dimethylaminopropyl acrylamide) (PDMAPAA) gel and the delivery was controlled by electrical stimulation. As seen in Fig. 15, periodic on and off release of the protein molecule was obtained with numerous alternating applications of an electric field [42]. The response of the gel is quite sharp, and no leakage of the insulin during the off time was observed. Similarly, endrophonium chloride was released in an of-off pattern from poly(AMPS) copolymers with electric stimuli [43]. 

Zhou et al. developed a novel aqueous thermoresponsive adsorbent material for DNA deposition. A 4-branched chain, starshaped copolymer was developed with each chain comprising a cationic poly(iV,iV-dimethylaminopropyl acrylamide] [PDMAPAAm] block forming the inner domain for DNA binding and a thermoresponsive poly(iV isopropylacrylamide] [PNIPAM] block, the most commonly used thermosensitive polymer, formed the outer domain for surface adsorption [42]. The copolymer and the luciferase-encoding plasmid DNA were complexed and polyplexes of size approximately 100 nm were obtained. The polyplex so formed exhibited LCST at 35°C and was deposited on the substrate by precipitation from an aqueous solution upon warming. Thus, enhancement in the transfection efficiency was observed. 

Figure 17-24. Monomers in a copolymer for viscosifying diesel N,N-dimethyl-acrylamide and N,N-dimethylaminopropyl methacrylamide.

Nonionic, anionic, and cationic VP copolymers are all available commercially to enhance the hydrophilic, hydrophobic, and ionic properties of PVP for specihc applications. Important comonomers include vinyl acetate (VA), acrylic acid (AA), vinyl alcohol, dimethy-laminoethylmethacrylate (DMAEMA), styrene, maleic anhydride, acrylamide, methyl methacrylate, lauryl methacrylate (LM), a-olelins, methacrylamido-propyltrimethyl ammonium chloride (MAPTAC), vinyl caprolactam (VCL), and dimethylaminopropyl-methacrylamide (DMAPMA). 

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