2-Butanol, 4-dimethylamino-1,2-diphenyl-3-methyl

Darvon alcohol [(+ )-(2S,3R)-4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol], 5, 231 8,184-185. 

SYNS ALGAFAN ANTALVIC DARVON HYDROCHLORIDE DEPRANCOL DEPROMIC DEVELIN DEXTROPROPOXYPHENE HYDROCHLORIDE DEXTROPROXYPHEN HYDROCHLORIDE d-4-DIMETHYLAMINO-3-METHYL-l,2-DIPHENYL-2-BUTANOL PROPIONATE HYDROCHLORIDE s-a-(2-(DIMETHYLAMINO)-l-METHYLETHYL)-a-PHENYLBENZENEETHANOL PROPIOATE HYDROCHLORIDE (+)-l,2-DIPHENYL-2-PROPIONOXY-3-METHYL-4-DIMETHYLAMINO-BUTANE HYDROCHLORIDE DOLENE DOLOCAP... 

N,N-DIMETH i LYMINO)-3 -METHYLAZOBENZENE see DUH600 d-4-DIMETHYLAMINO-3-METHYL-l,2-DIPHENYL-2-BUTANOL PROPIONATE HYDROCHLORIDE see PNA500... 

Propoxyphene Hydrochloride is C+)- < -4 (Dimethylamino)-J-methyl-l,2-diphenyl-2-butanol Propionate Hydrochloride. Since nomenclature can become very burdensome, references will be made to the common name, propoxyphene hydrochloride, whenever possible. 

REDUCTION, ASYMMETRIC (+H2S,3R)-4-Dimethylamino-3-methyl-l,2-diphenyl-2-3-methy 1-1,2-diphenyl- 2-butanol. 

E/PROPOXYPHENE 4-DIMETHYLAMINO-3-METHYL-1 2-DIPHENYL-2-BUTANOL PROPIO... 

LiAlHHR) or (S>bi-2-naphthol UA1H4-1,2(S)- JOC 52 702 (1987) diphenyl-3(R)-methyl-4-(dimethylamino)-2-butanol or potassium 9-0-( 1,2 5,6-di-O-iso-propylidene-a-D-glucofuranosyl)9-boratabi-cyclo[3.3.1]nonane... 

If an achiral ferrocene derivative is converted to a chiral one by chiral reagents or catalysts, this may be called an asymmetric synthesis. All asymmetric syntheses of ferrocene derivatives known so far are reductions of ferrocenyl ketones or aldehydes to chiral secondary alcohols. Early attempts to reduce benzoylferrocene by the Clemmensen procedure in (5)-l-methoxy-2-methylbutane as chiral solvent led to complex mixtures of products with low enantiomeric excess [65]. With (25, 3R)-4-dimethylamino-l,2-diphenyl-3-methyl-2-butanol as chiral modifier for the LiAlH4 reducing agent, the desired alcohol was formed with 53% ee (Fig. 4-9 a) [66]. An even better chiral ligand for LiAlH4 is natural quinine, which allows enantioselective reduction of several ferrocenyl ketones with up to 80% ee [67]. Inclusion complexes of ferrocenyl ketones with cyclodextrins can be reduced by NaBH4 with up to 84% enantioselectivity (Fig. 4-9 b) [68 — 70]. 

Table lists the results of the additions of both chiral and achiral alkoxytrialkylaluminates (20) to chiral a-keto esters (21). Some trends arc readily tqiparent (i) sodium is a superior cation as compared to lithium and potassium (entries 11-14) (ii) the configuration of the chiral moiety of the ester substrate dictates the facial preference (entries 1-7) and the preference follows the dictates of Prelog s rule (iii) there is an observable solvent effect with a preference for hexane/ether mixtures (iv) either (+)- or ( )-(2S,3/ )-4-dimethylamino-l,2-diphenyl-3-methyl-2-butanol (Darvon alcohol or (Zhirald) is the best of the... 

Darvon alcohol (+)- or ( )-(2S,3/ )-4-dimethylamino-l,2-diphenyl-3-methyl-2-butanol. 

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