Dimethyl phosphorofluoridate

Until this work began in Cambridge at the beginning of the war, the alkyl phosphorofluoridates had received practically no attention. Lange1 had given a tedious and laborious method for preparing dimethyl and diethyl phosphorofluoridates in very poor yield as follows. 

Dimethyl and diethyl phosphorofluoridate were hydrolysed much more quickly, the order being Me>Et>Pr complete hydrolysis of the ethyl ester took about 4 hr. Small quantities of the di-isopropyl, but not the diethyl ester, could be steam-distilled. Bi-isopropyl phosphorochloridate can be readily identified by allowing it to react with aniline to give the crystalline phenylphosphoramidate ... 

Nevertheless, there is some similarity of structure between compounds (II) and (IV). It is known that with grem.-diethyl groups in the phosphorofluoridate molecule, e.g. di-(l-ethyl- -propyl) phosphorofluoridate (V), the toxicity is less than with <7em.-dimethyl groups (di-isopropyl phosphorofluoridate (IV)). We found that similarly tetraethylphosphorodiamidic fluoride... 

Synonyms dimethyl phosphorolluoridate phosphorofluoridic acid dimethyl ester dimethoxyphosphoryl fluoride... 

Phosphorodithioic acid, mixed 0,0-bis (isobutyl and pentyl) esters, zinc salt. See Zinc dialkyl dithiophosphate Phosphorofluoridic acid, calcium salt. See Calcium monofluorophosphate Phosphorofluoridic acid, disodium salt. See Sodium fluorophosphate (Na2P03p) Phosphorofluoridic acid, monoammonium salt. See Ammonium monofluorophosphate Phosphorofluoridic acid, potassium salt. See Potassium monofluorophosphate Phosphorothioic acid. See Diazinon Phosphorothioic acid, S-((6-chloro-2-oxooxazxolo(4,5-b) pyridin-3(2H)-yl)methyl) 0,0-dimethyl ester. See Azamethiphos, Phosphorothioic acid, 0-(2,5-dichloro-4-iodophenyl) 0,0-dimethyl ester. See lodofenphos... 

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