1,1-Dimethyl-7-methoxy-1,2,3,4-tetrahydro

D-fMO MO-Nonitol, 2,6-anhydro-3,S,7-trideoxy-l-C-([hydroxy-(tetrahydro-2-methoxy-5,6-dimethyl-4-methylene-2 H-pyran-2-yl) acetyl] amino)-5,5-di methyl-1, S,9-tri-0-rriethyl-, 2R-[2( j(,2[S (5-q], 5P,6P] -... 

J-Pyran-2-acetamid, Ai-[[6-(2,3-dimethoxypropyl)tetrahydro-4-hydroxy-5,5-dimethyl-2H-pyran-2-yl]rriethoxymethyl]tetrahydro-a-hydroxy-2-methoxy-5,6-dimethyl-4-rTiethylene]-... 

A mixture consisting of 4 grams of 1,2,3,4-tetrahydro-4,4-dimethyl-7-methoxy-isochromane-dione-(1,3) (MP 95° to 97°C), 2.53 grams of 4-aminosulfonyl-phenyl-(2)-ethylamine and 150 ml of xylene was heated for 2 hours at its boiling point in an apparatus provided with a water separator. Thereafter, the reaction mixture was allowed to cool and was then vacuum-filtered, and the filter cake was recrystallized from n-propanoi in the presence of activated charcoal. 2.9 grams (58% of theory) of 1,2,3,4-tetrahydro-4,4-dimethyl-2-(p-amino-sulfonylphenyl-(2)-ethyl]-7-methoxy-isoquinolinedione-(1,3), MP 203° to 205°C, of the formula below were obtained. 

Acetoxy-A,-[(/f/5)-methoxy(phcnyl)methyl -2-[(2/f,5/ ,6/ )-tetrahydro-5,6-dimethyl-2-mcthoxy-4-methylene-2//-pyran-2-yl acctamide A,-(a-Methoxybenzyl)acetylpederamidc Typical Procedure48 ... 

Methyl-1,2-dihydro- 96 4-Methoxy- 1-methyl- 5 94 4-Methyl-1-methyl-1.2-dihydro- 594 l-Oxo-2,3-dimethyl-1,2,3,4-tetrahydro- 603... 

Such alkaloids are N, N-dimethyl tryptamine, 5-methoxy-N, N-dimethyl trypta-mine, and 2-methyl-1, 2, 3, 4-tetrahydro-fJ-carboline, which have been characterized from the resins of several Virola species, which is used by the witch doctors of several... 

Using a different dimerization method, namely phenolic oxidation, chiral substrates react in a more stereoselective manner than under reductive conditions. The choice of oxidizing reagent may drastically affect the stereochemical outcome of the reaction. Thus, when potassium hexacyanoferrate(III) is used (17 )-l,2,3,4-tetrahydro-6-methoxy-l,2-dimethyl-7-isoquino-linol couples to give a mixture of atropisomers 3 in 38 % yield and with a d.r. (M)I(P) of 45 553,4. Only one single atropisomer, namely (A/)-3, is formed, in a 66% yield by anodic oxidation, which is attributed to electrode surface effects3. 

HlS,3,S,)-2-Benzyl-l,2,3,4-tetrahydro-7-(2-hydroxymethyl-4,5-dimethoxy-l-naphthalenyl)-6-methoxy-l,3-dimethyl-8-isoquinolinol (7)1 12 ... 

Lewis acids have also been found to promote the electrophilic cleavage of cyclobutanes. The key feature of this reaction can be depicted by the conversion of the chiral 4-(2-hydroxy-6-methoxyphenyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-ones 5 and 4-(2-methoxy-6-hydroxyphenyl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-ones 7 to (6a5, 10a/ )-(-)-l-methoxy-6,6a,7,8,10,10a-hexahydro-6,6-dimethyl-9//-dibenzo[b,c/]pyran-9-ones 6 and (6aS)-( + )-methoxy-6,6a,7,8-tetrahydro-6,6-dimethyl-9//-dibcnzo[b//]pyran-9-ones 8, respectively, on treatment with either tin(IV) chloride in chloroform or with aluminum trichloride in dichloromethane.52... 

Dioxo-l,4,7,10-tetrahydro-l,10-phenanthroline (72) with dimethyl sulfate gives l,4-dihydro-7-methoxy-l-methyl-4-oxo- 1,10-phenanthroline (73) rather than a quaternary salt, steric hindrance presumably preventing alkylation of both nitrogens.203 A related alkylation has also been reported.295 1,2,3,4-Tetrahydro-1,10-phenanthrolines similarly form 1-alkyl derivatives rather than 10-alkyl quaternary salts with alkyl halides.38 The rate of methylation of 1,10-phenanthroline with methyl iodide in dimethyl sulfoxide has been studied,296 and the polaro-graphic reduction of 1 -methyl- 1,10-phenanthrolinium iodide was reported.286... 

The structures of anhydro 9,9-dimethyl-4-hydroxy-2-oxo-6,7,8,9-tetrahy-dro-2H-pyrido[2,l- >] [1,3]thiazinium hydroxide (95JOC3795,95T6651) and llh-isopropyl-2-methoxy-3,4-diphenyl-2,6,7,llh-tetrahydro-[l,3]thiazino-[2,3-a]isoquinoline [79AX(B)1285] were determined by means of X-ray diffraction analysis. 

IH-Azepine. hexahydro-2-propyl- (85028-29-1), 66, 193 2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy-, 67,170 2-AZETIDINONE, 4-(ACETYLOXY)-, 65,135 2-AZETIDINONE, 4-HYDROXY-ACETATE (ESTER), 65, 135 2-AZETIDINONE, 3-METHOXY-1.3-DIMETHYL-4-PHENYL-, 65, 140 Azobisisobutyronitrile (AIBN) (78-67-1), 66, 77, 79, 86 67, 86 69, 66 AZOMETHINE YLIDE EQUIVALENT, 67,133... 

Subsequently, the reaction mixture was stirred for 5 hours on an ice bath and was then allowed to stand overnight at -2°C. Thereafter, the reaction solution was admixed with water, the precipitate formed thereby was separated by vacuum-filtration, the filtrate was admixed with more water, and the aqueous solution was acidified with 2N hydrochloric acid. A greasy substance precipitated out which crystallized after a brief period of contact with boiling methanol. 2.6 grams (85% of theory) of l,2,3,4-tetrahydro-2-[p-(N -cyclohexyl-ureido-N-sulfonyl)-phenethyl]-4,4-dimethyl-7-methoxy-isoquinolinedione-(l,3), MP 180° to 182°C, were obtained. 

Isomerization of benzo[/]-l,5-diazabicyclo[3,2,2]nonene in 8.8 N HBr at 140°C yielded l,2,3,5,6,7-hexahydropyrido[l,2,3-de]quinoxaline (83 KGS677). Photolysis of dimethyl l-(quinolin-8-yl)-l,2,3-triazole-4,5-di-carboxylates in MeCN resulted in stable an/tydro-2,3-dimethoxycarbonyl-3//-pyrido[l,2,3-de]quinoxalin-4-ium hydroxides [87JCS(P1)403]. 6-Hy-droxymethyl-2-methyl-7-methoxy-l,2,3,4-tetrahydro-6//-pyrazino-[1,2-h]isoquinolin-4-one (138) was prepared from 5- [A-methyl-Ar-(ethoxy-... 

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