Virola species

Such alkaloids are N, N-dimethyl tryptamine, 5-methoxy-N, N-dimethyl trypta-mine, and 2-methyl-1, 2, 3, 4-tetrahydro-fJ-carboline, which have been characterized from the resins of several Virola species, which is used by the witch doctors of several... 

In 1954, Stomberg isolated 5-methoxy-DMT from seeds of A. pere-grina. Later, DMT, DMT-N-oxide and 5-hydroxy-DMT-N-oxide were also found in A. peregrma. Additional components contributing to psychoactivity have been identified these also appear in about the same proportions in the Virola species used to make paricd. However, a Waikd snuff made from V. theiodora resin has an unusually high alkaloid content of up to 11 percent, consisting mainly of 5-methoxy-DMT (8 percent) and substantial amounts of DMT. 

As well as known 5-oxytryptamine typ>es, Virola species, used in the preparation of intoxicating snuffs, contain 6-methoxy-2-methyl-l,2,3,4-tetrahydro-/5-carboline and 6-methoxy-l,2-dimethyl-l,2,3,4-tetrahydro-)8-carboline. An isomer of this last alkaloid, 6-methoxy-2,9-dimethyl-l,2,3,4-tetrahydro-)8-carboline, has been isolated from Phalaris arundinacea. 

Blair, G. E., J. M. Cassady, J. E. Robbers, V. E. Tyler, and R. F. Raffauf Chemical Investigation of Virola Species. I. Isolation of 3,4, 5-Trimethoxy-/rflM5-stilbene, Otobaene and Hydroxyotobain from Virola cuspidata. Phytochem. 8, 497 (1969). 

Kijjoa A, Giesbrecht A M, Gottlieb O R, Gottlieb H E 1981 1,3-Diaryl-propanes and propan-2-ols from Virola species. Phytochemistry 20 1385-1388... 

Fernandes JB, Nilce Des Ribeiro MN, Gottlieb OR, Gottlieb HE 1980 Chemistry of Brazilian Myristicaceae. Part 13. Eusiderins and 1,3-diarylpropanes from Virola species. Phytochemistry 19 1523-1525... 

Our interest in the biosynthesis of lignans from Amazonian plant species (e.g., the Myristicaceae such as in Virola species) stemmed from four considerations (1) the growing interest in the physiological and... 

---