3.7- Dimethyl-l,6-octadien

The plant is strongly aromatic on account of an essential oil which comprises cis-a-ocimene (25.11%), 3,7-dimethyl-l,6-octadien-3 ol (16.85%), and trans-nerolidol (13.89%), hence the use of the plant in aromatherapy. A methanolic extract of bark of Litsea cubeba (Lour.) Pers. and its fractions (0.01 mg/mL) from bark inhibit NO and PGE2 production in LPS-activated RAW 264.7 macrophages without significant cytotoxicity at less than 0.01 mg/mL concentration. The methanol extract decreased the enzymatic activity of myeloperoxidase (0.05 mg/mL). These findings suggest that L. cubeba is beneficial for inflammatory conditions and may contain compound(s) with anti-inflammatory properties (63). Can we expect the vasorelaxant laurotetanine (64) isolated from the plant to exert such activity ... 

Preparation of (—)-Citronellol from Optically Active Pinenes. (+)-ci5-Pinane is readily synthesized by hydrogenation of (+)-0 -pinene or (+)-/3-pinene, and is then pyrolyzed to give (+)-3,7-dimethyl-l,6-octadiene. This compound is converted into (-)-citronellol (97% purity) by reaction with triisobutylalumi-num or diisobutylaluminum hydride, followed by air oxidation and hydrolysis of the resulting aluminum alcoholate [50]. 

Dimethyl-l,6-octadien-3-ol Dipentene Duboisine Linalool ( )-Limonene L-Hyoscyamine... 

ALLYLICALLY TRANSPOSED AMINES FROM ALLYLIC ALCOHOLS 3,7-DIMETHYL-l,6-OCTADIEN-3-AMINE... 

Linalool (3,7-dimethyl-l,6-octadien-3-ol) (62) occurs as one of its enantiomers in many essential oils, where it is often the main component. (/ )-(-)-Linalool for example occurs at a concentration of 80-85% in Ho oils from Cinnamomum camphora rosewood oil contains ca 80%. (S)-(+)-Linalool makes up 60-70% of coriander oil [26]. 

Dimethyl-l, 6-octadien-3-ylacetate (Linaiyl-acetate) p-Aminoazobenzene (pAAB) 196.3 0.956 (23) ... 

Dimethyl-l,6-octadien-3-ol, 518 ( )-3,7-Dimethyl-2,6-octadien-l-ol, 498 cis-3,7-Dimethyl-2,6-octadien-1 -ol, 53 frans-3,7-Dimethyl-2,6-octadien-l-ol, 498... 

SYNS ALLO-OCIMENOL 2,6-DIMETHYL-2,7-OCTADIENE-6-OL 2,6-DIMETHYLOCTA-2,7-DIEN-6-OL 3,7-DIMETHYLOCTA-l,6-DIEN-3-OL 3,7-DIMETHYL-l,6-OCTADIEN-3-OL FEMA No. 2635 LINALOL UNALYL ALCOHOL... 

SYNS ACETIC ACID LINALOOL ESTER BERGAMIOL 3,7-DIMETHYL-l,6-OCTADIEN-3-OL ACETATE 3,7-DIMETHYL-l,6-OCTADIEN-3-YL ACETATE FEMA No. 2636 LICAREOL ACETATE LINALOL ACETATE LINALOOL ACETATE... 

SYNS 3,7-DIMETHYl l,6-OCTADIEN-3-OL BENZOATE 3,7-DIMETHYL-1.6-OCTADIEN-3-YL BENZOATE... 

SYNS 3,7-DLMETHYL-l,6-OCTADIEN-3-OL ISOBU-TYRATE 3,7-DIMETHYL-l,6-OCTADIEN-3-YL ISOBUTYRATE l,5-DIMETHYL-l-VINYL-4-HEXENYL ESTER, ISOBUTYRIC ACID FEMA No. 2640 LINALOOL ISOBUTYRATE... 

Figure 5.1a (1) cis and trans linalool oxide (5-ethenyltetrahydro-a,a,5-trirnethyl-2-furanmethanol) (furanic form) (2) linalool (3,7-dimethyl-l,6-octadien-3-ol) (3) a-terpineol (a,a,4-trimethyl-3-cycloexene-l-methanol) (4) (Z,E) ocimenol (2,6-dimethyl-5,7-octen-2-ol) (5) cis and trans linalool oxide (pyranic form) (6) citronellol (3,7-dimethyl-6-octen-l-ol) (7) nerol (Z), geraniol (E) (3,7-di-methyl-2,6-octadien-l-ol) (8) Ho-diendiol I (3,7-dimethyl-l,5-octadiene-3,7-diol) (9) endiol (3,7-dimethyl-l-octene-3,7-diol) (10) Ho-diendiol II (3,7-dimethyl-l,7-... 

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