1.2- dimethyl-2-iodo

Dimethyl iodo(4-pentenyl)malonate (926) undergoes a Pd-catalyzed intramolecular radical-type reaction to form the alkyl iodides 927 and 928. rather than a Heck-type reaction product(775]. The same products are also obtained by a radical reaction promoted by tin hydride(776]. Although yield was low, a similar cyclization of the n-chloro ester 929 to form the seven-membered ring 930 was ob,served(777(. 

Platin(IV) Bis-[trimethylarsan]-dimethyl-iodo-(trideutero-methyl)- XIII/9a, 832... 

Cobalt Dimethyl-iodo-tris-[trime-thylphosphan]- XIU/9b, 116... 

Bipyridine and phenanthroline are employed as auxiliary ligands of the alkylplatinum(iv) complexes, for example, 921-923, and methyl(iodo)bis(thiolato)-platinum(iv) complexes are obtained as a mixture of the two geometrical isomers 924 and 925. The dimethyl(iodo)phenoxoplatinum(iv) complex 926 has also been prepared. Halogenation of the five-coordinated olefin-platinum(ii) complex with a phen ligand affords the Pt(iv) complex with three halides and a halogenoalkyl ligand. 

A dimethylplatinum(ii) complex having monoimine of ethylenediamine with 9-phenanthraldehyde undergoes oxidative addition of Mel to afford dimethyl(iodo)platinum(iv) complex with terdentate C,jV,A-ligand. Complex 1029 with a six-membered cyclometallated imine ring and its isomer with a five-membered ring are obtained as a mixture (Equation (190)). ... 

Eig. 7. CycHc voltammograms for the reduction of 1.0 mAf [2,2 -ethylene-bis(nitrilomethyHdyne)diphenolato]nickel(II) in dimethyl formamide at a glassy carbon electrode, in A, the absence, and B and C the presence of 2.0 and 5.0 mAf 6-iodo-l-phenyl-l-hexyne, respectively (14). 

In some instances a carbon-carbon bond can be formed with C-nucleophiles. For example, 3-carboxamido-6-methylpyridazine is produced from 3-iodo-6-methylpyridazine by treatment with potassium cyanide in aqueous ethanol and l,3-dimethyl-6-oxo-l,6-dihydro-pyridazine-4-carboxylic acid from 4-chloro-l,3-dimethylpyridazin-6-(lH)-one by reaction with a mixture of cuprous chloride and potassium cyanide. Chloro-substituted pyridazines react with Grignard reagents. For example, 3,4,6-trichloropyridazine reacts with f-butyl-magnesium chloride to give 4-t-butyl-3,5,6-trichloro-l,4-dihydropyridazine (120) and 4,5-di-t-butyl-3,6-dichloro-l,4-dihydropyridazine (121) and both are converted into 4-t-butyl-3,6-dichloropyridazine (122 Scheme 38). 

The ease of displacing a chloro, bromo or iodo substituent in comparable pyrimidines by aminolysis is disappointingly similar. Using 2-halogeno-4,6-dimethyl- and 4-halogeno-... 

In contrast to the 3-substituted products above, 4-chloro-, 4-bromo- and 4-iodo-isoxazoles are readily prepared by direct halogenation of the corresponding isoxazoles, from 4-isoxazolediazonium salts by the Sandmeyer reaction, or by reaction of hydroxylamine with a-halo- 8-dicarbonyl compounds (62HC(l7)l, p. 66, 63AHC(2)365). 3,5-Bis(dimethyl-amino)-4-fluoroisoxazole has been synthesized by reaction of (Me2NCO)2CHF with hydroxylamine (78BSB391). 

Indazole, 5,5-dimethyl-3-trifluoromethyl-4,5-dihydro-trichomonacidal activity, 5, 291 Indazole, 2-ethoxycarbonyl-reactions, 5, 269 Indazole, 3-fluoro-synthesis, S, 263 Indazole, 1-germyl-synthesis, 5, 236 Indazole, 1-glycosyl-synthesis, 5, 289 Indazole, 2-glycosyl-synthesis, 5, 289 Indazole, halo-reactions, S, 266 Indazole, 2-hydroxy-methylation, 5, 269 Indazole, 3-hydroxy-reactions, S, 264 Indazole, 6-hydroxy-diazo coupling, 5, 86 Indazole, hydroxyphenyl-synthesis, S, 288 Indazole, 3-iodo-synthesis, S, 241 Indazole, l-isopropyl-3-phenyl-reduction, 5, 243 Indazole, 3-mercapto-1 -substituted tautomerism, 5, 265 Indazole, methoxy-... 

Indole, 3-hydroxymethyl-2-phenyl-stability, 4, 272 Indole, I-hydroxy-2-phenyl-synthesis, 4, 363 Indole, 2-iodo-synthesis, 4, 216 Indole, 3-iodo-reaetions, 4, 307 synthesis, 4, 216 Indole, 2-iodo-l-methyl-reaetions, 4, 307 Indole, 2-lithio-synthesis, 4, 308 Indole, 3-lithio-synthesis, 4, 308 Indole, 2-mereapto-tautomerism, 4, 38, 199 Indole, 3-mercapto-tautomerism, 4, 38, 199 Indole, 3-methoxy-synthesis, 4, 367 Indole, 5-methoxy-oxidation, 4, 248 Indole, 7-methoxy-2,3-dimethyl-aeetylation, 4, 219 benzoylation, 4, 219 Indole, 5-methoxy-l-methyl-reduetion, 4, 256 Indole, 5-methoxy-l-methyl-3-(2-dimethylaminoethyl)-reaetions... 

Isoxazole, 4-iodo-3,5-dimethyl-reactions, 6, 59 Isoxazole, 3-iodo-5-phenyl-synthesis, 6, 86 Isoxazole, 3-isopropenyl-oxidation, 6, 27, 54 polymerization, 6, 54 Isoxazole, 3-isopropenyl-5-methyI-polymers, 1, 282... 

Oxetane, 2-ethoxy-3,3-dimethyl-2-phenyl-thermolysis, 7, 372 Oxetane, 3-fluoro-synthesis, 7, 390 Oxetane, 3-fluoro-3-nitro-synthesis, 7, 391 Oxetane, 3-iodo-synthesis, 7, 390... 

Selenophene, 2,5-dimethyl-3-mercapto-synthesis, 4, 956 tautomerism, 4, 946 Selenophene, 2,4-diphenyl-synthesis, 4, 135 Selenophene, 2,5-diphenyl-lithiation, 4, 949 UV spectra, 4, 941 Selenophene, 2-ethoxycarbonyl-mercuration, 4, 946 Selenophene, halo-reactions, 4, 955 Selenophene, 2-hydroxy-Michael reaction, 4, 953 tautomerism, 4, 36, 945, 953 Selenophene, 3-hydroxy-tautomerism, 4, 36, 945 Selenophene, 3-hydroxy-2,5-dimethyl-tautomerism, 4, 945, 953 Selenophene, 2-hydroxy-5-methyl-methylation, 4, 953 tautomerism, 4, 945 Selenophene, 2-hydroxy-5-methylthio-tautomerism, 4, 945 Selenophene, 3-iodo-synthesis, 4, 955 Selenophene, 3-lithio-reactions, 4, 79 synthesis, 4, 955 Selenophene, 2-mercapto-tautomerism, 4, 38 Selenophene, 3-mercapto-tautomerism, 4, 38 Selenophene, 2-mercapto-5-methyl-synthesis, 4, 956 tautomerism, 4, 946 Selenophene, 3-methoxy-lithiation, 4, 949, 955 synthesis, 4, 955 Selenophene, methyl-oxidation, 4, 951 synthesis, 4, 963 Selenophene, 2-methyl-lithiation, 4, 949 Selenophene, 3-methyl-synthesis, 4, 963... 

The second method involves the direct reaction ofbromo- or lodofluoroolefinx with zinc powder [110] (equation 81) in solvents such as DMF, NJV-dimethyl-acetamide (DMAC), tnglyme, tetraglyme, THF, and CH3CN. In all cases, the stereochemistry is retained Table 4 shows some typical examples of this method ology Similar results are obtained with l-chloro-2 lodotetrafluorocyclobutene [III] and l-iodo-2-chlorohexafluorocyclopentene [112]... 

The 2,2 -bis(phenylthiomethyl) dispiroketal (dispoke) derivative is cleaved by oxidation to the sulfone, followed by treatment with LiN(TMS)2. The related bromo and iodo derivatives are cleaved reductively with LDBB (lithium 4,4 -di- -butylbiphenylide) or by elimination with the P4- -butylphosphazene base and acid hydrolysis of the enol ether. The 2,2-diphenyl dispiroketal is cleaved with FeCl3 (CH2CI2, rt, overnight)." The dimethyl dispiroketal is cleaved with TFA, and the allyl derivative is cleaved by ozonolysis followed by elimination. ... 

The condensation of 4-ethynyl-1,3-dimethyl-5-aminomethylpyrazole with iodo-benzene in the standard conditions of the Heck-Sonogashira reaction caused no complications and the yield of disubstituted acetylene was 87% (86TH1) (Scheme 68). 

O-isopropylidene derivative (57) must exist in pyridine solution in a conformation which favors anhydro-ring formation rather than elimination. Considerable degradation occurred when the 5-iodo derivative (63) was treated with silver fluoride in pyridine (36). The products, which were isolated in small yield, were identified as thymine and l-[2-(5-methylfuryl)]-thymine (65). This same compound (65) was formed in high yield when the 5 -mesylate 64 was treated with potassium tert-hx Xy -ate in dimethyl sulfoxide (16). The formation of 65 from 63 or 64 clearly involves the rearrangement of an intermediate 2, 4 -diene. In a different approach to the problem of introducing terminal unsaturation into pento-furanoid nucleosides, Robins and co-workers (32,37) have employed mild base catalyzed E2 elimination reactions. Thus, treatment of the 5 -tosylate (59) with potassium tert-butylate in tert-butyl alcohol afforded a high yield of the 4 -ene (60) (37). This reaction may proceed via the 2,5 ... 

Propane, 2-isocyanato- [1795 48-8], 96 Propane, 1 mtro [108-03-2, 36 1,3-Propanedithiol [109-80-8],9 Propanoic acid, 2-chloro- [598-78-7], 70 Propanoic acid, 2,2-dimethyl- [75-98-9], 70 Propanoic acid, 2-iodo-3-mtro-, ethyl ester [57621-01-9], 65... 

CioHi.jNOj 49831-65-4) see Calcium hopantenate 3P,5-dihydroxy-6p,17-dimethyl-5a-pregnan-20-one (C23H3JO1 95671-00-4) see Medrogestone lip,17-dihydroxy-3,20-dioxo-9a-fluoro-21-iodo-16P-methyl-l,4-pregnadiene... 

Halogenation of 106 with triphenylphosphine, iodine, and imidazole provided the iodo derivative 109. On treatment with lithium aluminum hydride, 109 was converted into two endocyclic alkenes, 110 and di-O-isopro-pylidenecyclohexanetetrol, in the ratio of 2 1. Oxidation of 110 with dimethyl sulfoxide - oxalyl chloride afforded the enone 111.1,4-Addition of ethyl 2-lithio-l,3-dithiane-2-carboxylate provided compound 112. Reduction of 112 with lithium aluminum hydride, and shortening of the side-chain, gave compound 113, which was converted into 114 by deprotection. ... 

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