2,6-Dimethyl-8-hydroxy-9-nitro

Nach dem SRN1-Mechanismus verlauft wahrscheinlich die Substitution der Nitro-Gruppe von l,2-Dimethyl-5-nitro-imidazol mit Natrium-1 -methyl-ethannitronat oder von l-(2-Hydroxy-ethyl)-2-methyl-5-nitro-imidazol (Metronidazol) mit 2-Amino-ethanthiol. 

Secnidazole. a,2-Dimethyl-S-nitro-lH-imida-tele-1 -erbanof 1 -(2 -hydroxy propyl) -2 -methyl -5 -nitroimid -azole ]-(2-methyl-5-nitroimidazol-l-yl)-2-propanol PM-185184 RP-14539 Flagentyl. C,HllNJ0J mol wt 185.18. C 45.40%, H 5.99%, N 22,69%. O 25.92%. Analog... 

Armstrong et al. [110) studied 19 sets, with two to five compounds in each set, of structural isomers (e.g., cresols and xylenes to methylindoles and prostaglandins) on a ) -cyclodextrin colunm (X = 254 nm or 280 nm). Good peak shapes and resolution were obtained for all sets using mobile phases ranging from 30/70 methanol/water (for cresols) to 90/10 methanol/water (for vitamin D2). It was noted that retention for disubstituted benzenes (e.g., the hydroxy/methyl, dimethyl, nitto/hydroxy, nitro/amine and amine/carboxy substituent pairs) usually decreased in the order para > ortho > meta on the ) -cyclodextrin column. 

Dimethoxy-5-nitro-2-phenylpyrimidine heated 15 min. at 200° without solvent anhydro -4- hydroxy -1,3- dimethyl - 5 - nitro -6- oxo-2- phenylpyrimidinium hydroxide. Y 80%. F. e. s. Y. Maki, M. Sako, and M. Suzuki, Chem. Commun. 1972, 999. 

When large groups, such as phenyl, bromo, ethoxycarbonyl or nitro are attached at position 3, the principal products are l-alkylcinnolin-4(l/f)-ones. Cyanoethylation and acetylation of cinnolin-4(l/f)-one takes place exclusively at N-1. Phthalazin-l(2/f)-ones give 2-substituted derivatives on alkylation and acylation. Alkylation of 4-hydroxyphthala2in-l(2/f)-one with an equimolar amount of primary halide in the presence of a base leads to 2-alkyl-4-hydroxyphthalazin-l(2/f)-one and further alkylation results in the formation of 4-alkoxy-2-alkylphthalazinone. Methylation of 4-hydroxy-2-methyl-phthalazinone with dimethyl sulfate in aqueous alkali gives a mixture of 4-methoxy-2-methylphthalazin-l(2/f)-one and 2,3-dimethylphthalazine-l,4(2//,3//)-dione, whereas methylation of 4-methoxyphthalazin-l(2/f)-one under similar conditions affords only 4-methoxy-2-methylphthalazinone. 

Furoxans, diethyl-synthesis, 6, 423 Furoxans, dihalo-synthesis, 6, 423 Furoxans, dimethyl-NMR, 6, 397 O NMR, 6, 398 Furoxans, diphenylring cleavage, 6, 404 synthesis, 6, 423 Furoxans, hydroxy-reactions, 6, 414 Furoxans, mercapto-reaotions, 6, 414 Furoxans, nitro-as explosives, 6, 426 reactions, 6, 413-414 reduction, 6, 423 Furoxans, phenyl-reactions... 

Diorganotin(IV) complexes with 4//-pyrido[l,2-n]pyrimidin-4-ones 109 (96MI4), complexes of 2-methyl- and 2-methyl-8-nitro-9-hydroxy-4//-pyrido[l,2-n]pyrimidin-4-ones with Ag(I), Cu(II), Ni(II), Co(II), and Mn(II) ions (00MI23), 2,4-dimethyl-9-hydroxypyrido[l, 2-n]pyrimidinium perchlorate and its complexes with prasedynium, neodymium, samarium and europium (00MI24) were characterized by UV spectroscopy. 

Diorganotin(IV) complexes (109) were prepared from 4/f-pyrido[l,2-a]pyrimidin-4-ones with Me2SnCl2 and Ph2SnCl2 in dry CHCI3 (96MI4). Different complexes of 2-methyl-9-hydroxy-4//-pyrido[l, 2-n]pyrimidin-4-one and its 8-nitro derivative were prepared with Cu(I)Cl, Cu(II)Cl2, Ni(II)Cl2, Co(II)Cl2, Mn(II)Cl2, and Ag(I)N03 m EtOH (00MI23). Complexes of 2,4-dimethyl-9-hydroxypyrido[l,2-n]pyrimidinium salt were obtained with Pr(III), Nd(III), Sm(III), and Eu(III) ions in acetone (00MI24). 

Bis- 3-(bzw.4)-[2,2-dimethyl-2-(2-hydroxy-propyl)-1 -dehydro-hydrazinocarbonyl]-phenyl - 687 Bis-[2-methy]-phenyl]- 538 -bis-phosphonsaure-diester 523 Bis-[trifluormethy]]- 538 tert.-Butyl-( 1-hydroperoxy-cyclopentyl)- 571 tert.-Butyl-( 1 -hydroxy-cyclopentyl)- 571 (4-Chlor-phenyl)-(2-nitro-phenyl)- 693 (4-Chlor-phenylthio)-(4-nitro-phenyl)- 700 [Cyclohexen-(l)-yl]-phenyl- 368 Diaryl- 550, 552, 558, 567 Diphenyl-... 

Acetyl-phenyl- 635 4-Amino-3,5-dimethyl-phenyl- 102 2-Amino-4-hydroxy-phenyl- 692 4-Amino-phenyl- 685 4-Benzylamino-phenyl- 102 2,4-Dinitro-phenyl- 692 4-(2-Hydroxy-benzylamino)-phenyl- 102 2-(2-Methyl-butanoyl)-phenyl- 635 4-Methoxy-2,6-dimethyl-phenyl-102 (Nitro-phenyl)- 635 2-Nitro-phenyl- 680, 692 4-Nitro-phenyl- 685... 

Dimethylamino-methyl)-2-hydroxymethyl-aus 2 -Carboxy-2-(dimethylaminocarbonyl)-biphenyl und Lithiumalanat 165 2,2 -Dinitro- 474, 476, 695 6,6 -Dinitro-2,2 -bis-[chlorcarbonyl]- 188 2,2 -Dinitro-4,4 -bis-[diathylamino]- 695 4,4 -Dinitro-2,2 -bis-rhydroxymethyl]- 213 6,6 -Dinitro-2,2 -bis-[hydroxymethyl]- 188 2,2 -Dinitro-4,4 -diamino- 695 6,6 -Dinitro-2,2 -diformyl- 694 4,4 -Dinitro-2,2 -dimethoxycarbonyl- 213 2,2 -Dinitro-4,4 -dimethyl- 695 6,6 -Dinitro-2 -formyl-2-carboxy- 694 2,2 -Dinitroso- 476 -4-hydroxamsaure-chlorid 537 4-(a-Hydroxy-benzyl)- 542 Methoxy- 678 2-Methyl- 556 Nitro- 672, 678 4-Nitro- 687... 

Fig. 5 Structure of dyes forming aggregates in membranes (a) 2-[( )-2-[2-hydroxy-5-nitro-3-ll(Toxodocosyl)oxy]methyl]phenyl]ethenyl]-3,3-dimethyl- l-octadecyl-3//-indolium (PMC),...

Diethyl-7-nitro-4,5-dimethyl-3-hydroxy-2,3-dihydr obenzimida-zole, see Pendlmethalin... 

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