Dimethyl-4-amino aniline

Dimethylamine chlordimefoim, chloromethiuron, chloroxuron, chlorotoluron, crimidine, dichlofluanid, dicrotophos, difenoxuron, dimefuron, dimethirimol, diphenamid, diuron, fenothiocarb, fenuron, ferbam, fluometuron, hexazinone, isoproturon, karbutilate, metoxuron, metribuzin, monuron, nicosulfuron, oxamyl, pirimicarb, pyrithiobac, thiram, tolyfluanid, triazamate, ziram 4 Dimethyl amino aniline fenaminosulf 2 Dimethyl amino 1,3 dichloro propane bensultap, thiocyclam N-N -Dimethylamino dimethyl aluminum nicosulfuron 2 Dimethyl amino 1,3 Dithiobenzyl propane thiocyclam 4 Dimethyl amino 3 methyl phenol aminocarb... 

BenzoIazo>N>[4.4 -bi8-methy]amino-3.3 -dimethyl>b8mhydTyl]-anilin 16, 319. 

The most relevant structural features of this new class of SPS co-crystals is that suitable guests are not only small molecules (both essentially apolar, like DCE[55] and highly polar, like 4-nitro-aniline [53]) but also long molecules like 4-(dimethyl-amino)-cinnamaldehyde, which exhibit a molecular volume too large to be enclosed as a guest into the 8 phase. 

Oxidative Couplings of Heterocyclic Hydrazones. This method has opened the way to the preparation of azo derivatives of diazo compounds unobtainable by other means, ie, heterocycHc compounds ia which the diazotizable amino group is conjugated with the heterocycHc nitrogen atom as ia 2- and 4-amiQopyridine, compounds which do not normally yield stable diazonium salts (38). The reaction occurs as illustrated by equation 7 for the iateraction of (A/-methylcarbostyryl)hydrazone [28219-37-6] and dimethyl aniline the overall process is oxidation. 

Some substituents such as the acylamino group are readily decomposed by many nucleophiles to give a poorer leaving group (e.g., amino). Others, such as nitroamino and sulfonylamino, are less reactive when they are anionized by the nucleophile. 3-Nitroamino-pyridazine (117) and its 6-methyl derivative are readily aminated with benzylamine (130°, short time ). 4,6-Dimethyl- and 6-methyl-2-nitroaminopyrimidine undergo 2-substitution on warming a few minutes with hydroxylamine, hydrazine, primary or secondary alkylamines, or anilines. 

The 3-amino-8-oxo derivative of 1,2,4,5,7-pentaazanaphthalene (475) is known as well as various 3-substituted derivatives of the 6,8-dioxo compound. The 3-methylthio- and 3-ethylthio-6,8-dioxo derivatives and their 7-methyl and 5,7-dimethyl analogs were prepared by ring-closure. 3-Ethylthiopyrimido[4,5-e]-as-triazine-6,8-dione was 3-substituted with alkali 2N, 100°, > 30 min) or acid 2N, 100°, < 2 hr, 70% yield) and with ammonia, aniline, piperidine, or monoalkylamines (in pyridine, 115°, 4 hr, 75-85% yield). ... 

Finally, Katritzky et al.sii have measured first-order rate coefficients for deuteration of pyrimidines by deuterated sulphuric acid (Table 152), and all pD and —D0 values given in the Table refer, as in the earlier work, to a temperature of 20 °C. For 2-aminopyrimidine, reaction clearly occurs on the free base and comparison of the data with the earlier work on anilines and by making a number of assumptions, conjugate acid at higher acidities is apparent and this follows the previously established pattern. This work yielded a value of 0.55 for [Pg.236]

Frejd and co-workers utilized a different tactic for aniline cyclization by first employing a Heck-Jeffery protocol under solvent-free conditions to prepare o-amino dehydrophenylalanine derivatives from o-aminoaryl iodides with the former undergoing a spontaneous la cyclization-elimination sequence to afford 2-methoxycarbonyl indoles <06S1183>. Dimethyl(methylthio)sulfonium trifluoromethanesulfonate (DMTST) was used by the Okuma group to promote the cyclization of o-vinyl-A-p-toluenesulfonylanilide to N-tosylindole <06CL1122>. 

Electron-donating substituents in the aniline, such as methyl or methoxy groups, especially at the meta position, promote coupling the tendency to couple thus increases in the order aniline< o -to 1 uidine< w -toluidinc < m -anisidi ne< cresi-dinedimethyl ether) to the extent that without formation of the diazoamino compound, the last three bases are attached almost quantitatively in the desired position, i.e., at the 4-position relative to the amino group. 

Aminopyrazines are conveniently prepared from carboxamido-pyrazines by application of the Hofmann reaction (see Section V,B). Thus, Camerino and Palamidessi prepared aminopyrazine in 80% yield from carboxamidopyrazine.312 Aminopyrazine may also be prepared from the reaction of pyrazine with sodamide in liquid ammonia,313 and 3-amino-2,5-dimethylpyrazine is the product of amination of 2,5-dimethylpyrazine with sodamide in dimethyl-aniline.311 The ammonolysis of halopyrazines also represents a useful preparative procedure for aminopyrazines (see Section V,C). This reaction proceeds most easily in the case of fluoro compounds for example, fluoropyrazine is converted into aminopyrazine in 70% yield by treatment with concentrated aqueous ammonia at room temperature for 3 days,299 whereas the corresponding reaction with chloropyrazine has been carried out in a sealed tube at 150°.147 Alkaline hydrolysis of 2,4-dihydroxypteridines followed by decarboxylation yields aminopyrazines 315 thus, high-temperature alkaline hydrolysis of 7-methyl-2,4-dihydroxypteridine (7-methyIlumazine) gives, after decarboxylation of the intermediate pyrazinecarboxylic... 

Amino 2,4 dimethyl aniline mefluidide Amino guanidine amitrole... 

This rare synthesis has been used to advantage in the conversion of N,N-bis (2-amino-l-methoxycarbonylvinyl)aniline (8) into dimethyl 1-phenyl-1,4-dihydro-... 

Attack other than on the amino group apparently does represent a competitive reaction course when the substituents on the aromatic ring are less electronegative than the nitro group. This is demonstrated by the strong coloration and tar formation observed when N,IV-dimethyl-aniline and p-chloro-N,A7-dimethylaniline are ozonized and by the fact that more ozone is consumed by these compounds than can be accounted for by side chain oxidation (Table III, Experiments 1 and 2). 

Anilin 2-(i-Piperidinoamino-ethyl)-E16a, 546 (Hydrazon-Red.) Piperazin l-Amino-4-benzyl-2,6-dimethyl- E16a, 490 (R2N—NO-Red.)... 

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