Dimeric macrolides

The macrolide halichondramide (3)62 showed more than 75% mortality (100 ppm) against newly hatched larvae of the southern com rootworm, Diabrotica undecimpunctata howardi, and the tobacco budworm, Heliothis virescens.44 The dimeric macrolides swinholide A and... 

Tanaka, J., Higa, T., Kobayashi, M., and Kitagawa, I. (1990). Marine natural products. XXFV. The absolute stereostructure of misakinolide A, a potent cytotoxic dimeric macrolide from an Okinawan marine sponge Theonella. sp. Chem. Pharm. Bull. 38, 2967-2970. 

Kretschmer M, Dieckmann M, Li P, Rudolph S, Herkommer D, Troendlin J, Menche D (2013) Modular total synthesis of rhizopodin a highly potent G-actin dimerizing macrolide. Chem Eur J 19 15993-16018... 

Doi M, Ishida T, Kobayashi M, Kitagawa I. Molecular conformation of swinholide A, a potent cytotoxic dimeric macrolide from the okinawan marine sponge theoneUa swinhoei - X-ray crystal structure of its diketone derivative. J. Org. Chem. 1991 56 3629-3632. 

Kobayashi, M., Tanaka, J.-I., Katori, T, and Kitagawa, 1. (1990d) Marine natural products. XXIII. Three new cytotoxic dimeric macrolides, swinholides B and C and isoswinholide A, congeners of swinholide... 

Rao, M.R. and Eaulkner, D.J. (2002a) Clavosolides A and B, dimeric macrolides from the Philippines sponge Myriastra clavosa. J. Nat. Prod., 65, 366-368. 

Saito, S.Y., Watabe, S Ozaki, H., Kobayashi, M., Suzuki, T, Kobayashi, H Fusetani, N and Karaki, H. (1998) Actin-depolymerizing efiect of dimeric macrolides, bistheonellide A and swinholide A. J. Biochem. (Tokyo), 123, 571-578. 

Nakamura, R., Tanino, K., and Miyashita, M. (2005) Stereoselective synthesis of premisakinolide A, the monomeric counterpart of the marine 40-membered dimeric macrolide misakinolide A. Org. Lett., 7, 2929-2932. 

Paterson, I. and Gumming, J.G. (1992) A stereocontrolled synthesis of a C19-C32/C17-C30 segment for swinholide A and misakinolide A, cytotoxic dimeric macrolides from Theonella swinhoei. Tetrahedron Lett., 33, 2847-2850. 

Erickson, K.L., Gustafson, K.R., Pannell, L.K., Beutler, JA., and Boyd, M.R. (2002) New dimeric macrolide glycosides from the marine sponge Myriastra davosa, J, Nat, Prod., 65,1303-1306. 

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