Dihydroxy arsine

Lewisite is practically insoluble in water, but the small amount that dissolves is rapidly hydrolyzed (Rosenblatt et al., 1975), resulting in the formation of the water-soluble dihydroxy arsine or 2-chlorovinyl arsonous acid. Lewisite in solution becomes essentially 100% 2-chlorovinyl arsonous acid (Major, 1998) ... 

Epstein 1956 MacNaughton and Brewer 1994 Rosenblatt et al. 1975). In slightly acidic solutions, lewisite first undergoes a rapid and reversible reaction to the dihydroxy arsine ... 

Although Lewisite is only slightly soluble in water (0.5 g L j [123], hydrolysis is rapid and results in the formation of the water-soluble dihydroxy arsine (2-chlorovinyl arsonous acid). In basic solution, the traws-Lewisite isomer is cleaved by the hydroxyl ion to give acetylene and sodium arsenite this occurs even at low temperatures [79, 123]. ds-Lewisite must be heated to over 40°C to react with NaOH to yield vinyl chloride, sodium arsenite and acetylene. In aqueous solution, the ds-isomer undergoes a photoconversion into the tr zws-isomer. In water and in the presence of oxidizers naturally present in the environment, the toxic trivalent arsenic of Lewisite oxide is oxidized to the less toxic pentavalent arsenic [124]. Regardless of the degradation pathway, arsenical compounds will ultimately be formed. 

C14H13ASO4 2,4 -Dihydroxy-3,3 -dimethyldiphenyl-arsinic acid (o-Cresol) 62... 

The foregoing acids are crystalline solids, and in some cases may be crystallised from water. 5-Amino-2 4-dihydroxy-, 3 5-diamino-2-hydroxy-, and 4 5-diamino - 2 - hydroxyphenylarsinic acids reduce ammoniacal silver nitrate solution, the reaction being instantaneous with the latter two acids. 4-Acetylamino-8-hydroxy-2-nitrophenylarsinic acid, boiled with 2N sulphuric acid, yields 2 6-nitroaininophenol, but with potassium hydroxide the acetyl group is merely hydrolysed reduction of the acid with ferrous chloride produces the corresponding diamine. 3-Amino-4-hydroxyphenylarsinic acid tends to oxidise when recrystaUised from water, and when a cooled solution of the acid in 5 per cent, sodium hydroxide solution is treated with carbonyl chloride, it gives 1 2-dihydrobenzoxazolone-4-arsinic acid. 8-Amino-4-hydroxy-phenylarsinic acid also yields a number of N-acyl derivatives (see details on p. 296), the most important of which is the 8-acetylamino-compound,... 

Dihydroxy-1 4-benzisoxazine-6-arsinic acid, formed by the ehloracetylation in alkaline solution of 5-amino-2 4-dihydroxj -phenylarsinic acid, crystallises from boiling water in plates, unmelted at 300° C. Its barium salt forms colourless prisms from boiling water, but the calcium and magnesium salts are amorphous. 

Few optically active tertiary arsines are known that owe their optical activity to a chiral substituent. The first comjX)unds of this type to be reported were the enantiomers of R, R )-2,3-0-isopropyIidene-2,3-dihydroxy-1,4-bis(diphenylarsino)butane (diarsop) The enantiomers of the bis(tertiary arsine), (f ,/ )-(-l-)-170 and (S,S)-(—)-170, were synthesized from the ditosylates of commercially available (R,R)- —)- and (S,S)-(-)-)-2,3-0-isopropyIidenethreitol by treatment with potassium diphenylarsenide-2-dioxane. The compounds are air-stable crystalline solids, mp 64-66 °C (Table 9). A similar preparation of (S,S)-( —)-170 was reported in the same year . ... 

Chlorovinyl arsonous acid (CVA) 2-Chlorovinyl arsenous acid 2-Chloroethenyl arsonous acid Dihydroxy(2-Chlorovinyl)arsine 2-Chloroethenyl dihydroxyarsine C2H4AsC102 85090-33-1 Hydrolysis of Lewisite... 

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