Dihydrostreptomycin sulphate

Singh, K., and Mezei, M. (1984). Liposomal ophthalmic drug delivery system. II. Dihydrostreptomycin sulphate, Int. J. Pharm.. 

Dicyclopentadiene dioxide Dihydrostreptomycin sulphate 3,3 -Dimethoxy 4,4 -diamino diphenyl Dimethylacridan... 

The application of chemometric procedures coupled with derivative spectroscopy permits achievement of higher selectivity in determination of P-lactam antibiotics. Currently, chemometric procedures based on the estimated ratio of spectra derivative for the selective determination of P-lactam analogs are the most common. It was proved that the application of the ratio of different-order spectra derivatives permitted the separation of binary and tertiary mixtures of P-lactam antibiotics [22]. During the determination of concentrations of three components (e.g., penicillin-G sodium, penicillin-G procain and dihydrostreptomycin sulphate salts) in a mixture the equation describing the ratio spectra derivative spetrophotometry is as follows ... 

The solubility of dihydrostreptomycin sulphate, which is water soluble, is decreased in concentrated solutions of sorbitan monolaurate (E = 12) [129]. Streptomycin sulphate is also very soluble in water and is incompatible with sodium lauryl sulphate. Combination of streptomycin with polysorbate 20 produces a strong bacteriostatic effect against antibiotic resistant bacteria. Intrapleural injection of 0.5 g dihydrostreptomycin with one drop of polysorbate 20 in 4 ml has been reported to result in a sterile pleural sample 1 week after injection [130]. 

Streptomycin and dihydrostreptomycin have very similar chemical structures and so many of the chemical methods which are available are equally applicable to both antibiotics. Certain procedures have a measure of specificity however and may be used for the determination of one of the substances in the presence of the other. The B.P. relies upon microbiological assay (see p. 813) for determination of the potency of both these antibiotics, which are official in the form of their sulphates. 

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