Digoxin elixirs

The dose of digoxin for rapid digitalization is a total of 1 mg in two divided doses at intervals of six to eight hours. How many milliliters of digoxin elixir containing 50 p,g/mL would provide this dose ... 

If a physician orders Lanoxin 0.25 mg p.o. q.d., how many milliliters of Lanoxin (digoxin) elixir containing 50 ig of digoxin per milliliter should be used ... 

Rofccoxib 75 mg once daily did not cause significant changes in the plasma pharmacokinetics or renal elimination of single 500-microgram doses of digoxin elixir. ... 

In a study in 40 healthy subjects trospium 20 mg twice daily for 12 days did not affect the pharmacokinetics of a single 500-microgram dose of digoxin elixir given on day 7. ... 

WJ Jusko, DR Conti, A Molson, P Kuritzky, J Giller, R Schultz. Digoxin absorption from tablets and elixir the effect of radiation-induced malabsorption. J Am Med Assoc 230 1554-1555, 1974. 

Lanoxin Elixir contains 50 jxg of digoxin/mL. How much additional digoxin should be added to 4 fluid ounces of the elixir so that each teaspoonful will contain 1 mg of digoxin ... 

Dosage adjustment when changing preparations The differenee in bioavailability between digoxin injeotion or oapsules and pediatrie elixir or tablets must be oonsidered when ohanging patients from 1 dosage form to another. 

Capsules Because of the more complete absorption of digoxin from soft capsules, recommended oral doses are only 80% of those for tablets and elixir. Because the significance of the higher peak serum concentrations associated with once daily capsules is not established, divided daily dosing is presently recommended for the following ... 

This is a stable solution of digoxin specially formulated for oral use in infants and children. Each milliliter contains 50 meg (0.05 mg) digoxin. The lime-flavored elixir contains the inactive ingredients alcohol 10%, methylparaben... 

Elixirs are sweetened hydroalcoholic oral solutions that are specially formulated for oral use in infants and children. Digoxin, a non-ionizable cardiotonic glycoside, is practically insoluble in water and is solubilized in propylene glycol, 10% ethanol, flavor, sweetener, preservative, and buffers to 50pg/ml in Lanoxin Elixir Pediatric from which the oral bioavailability of digoxin is 70-85%. Phenobarbital, an anticonvulsant and sedative with an intrinsic water solubility of 1 mg/ml, is solubilized in water, 23% ethanol, glucose, sodium saccharin, and flavors to 3.5 mg/ml in Donnatal Elixir. 

Figure 10.16 Adsorption of digoxin from Lanoxin paediatric elixir at 37 0.1 °C by , Aluminium Hydroxide Gel BP (10% v/v) A, Magnesium Trisilicate Mixture BPC (10% v/v) A, Gelusil suspension (10% v/v) , Lanoxin elixir diluted 1 10 with water.

Example The healthcare provider prescribed Elixir of Digoxin 15 meg per kilogram. The patient weighs 66 lb. The pharmacy delivers 50 meg per milliliter. 

Binary 40% Propylene glycol and 10% Ethanol PEG/propylene glycol Lanoxin Elixir Pediatric (Digoxin) Ghildren s Tylenol Cold (Acetaminophen, chlorpheniramine maleate, and dextromethorphan)... 

Broadhead J, Ruan SK, Rhodes CT. The effect of process and formulation properties on the properties of spray dried 3-galactosidase. J Pharm Pharmacol 1994 46 458-467. Kim CK, Soon YS. Development of digoxin dry elixir as a novel dosage form using a spray-drying technique. J Microencap 1995 12(5) 547-566. 

Elixirs and Injections. Pipette a volume of sample containing 1 25 mg of digoxin into a separator and proceed as described above under Crystalline Digoxin , beginning with the words add 50 ml of water.. . . . ... 

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