Diffuse optical tomography

Keywords functional brain monitoring near infrared spectroscopy diffuse optical tomography. 

Fluorescent CPMV [99] particles for imaging via diffuse optical tomography for biomedical applications... 

Wu, C., et al. (2005), Metal nanoshells as a contrast agent in near-infrared diffuse optical tomography, Opt. Commun., 253(1-3), 214-221. 

Ntziachristos, V., Yodh, A.G., Schnall, M., and Chance, B. (2000) Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement, Proc Natl Acad Sci USA 97, 2767-2772. 

Didodecyldimethylammonium bromide (DDAB) 1508-1509 Diethyl maleate 1466 Diethylentriaminepentaacetate 1123 Diffuse optical tomography (DOT) 1223 DiGeorge syndrome 220 Digitalis 835 Digoxin 58... 

Time-of-Flight. The term is used in experiments of high-energy physics, mass spectroscopy, and diffuse optical tomography (DOT). The TOF-distribution in DOT is the distribution of the photons versus time after propagation through a turbid medium. Fluorescence lifetime spectroscopy r is used for the fluorescence lifetime or the lifetime components in multiexponential decay functions. rn=natural lifetime in the (hypothetical) absence of all nonradiative decay processes, To = observed lifetime in the absence of external quenching processes, Tmt rotational depolarisation time. 

The Continuous Flow mode is useful in all applications which require a large number of curves to be recorded in time intervals down to the 100 us scale. Typical applications are dynamic brain imaging by diffuse optical tomography (DOT) [328], and single-molecule detection in a capillary gel electrophoresis setup [31]. 

With a dead time of 100 ns per TCSPC channel, total useful count rates of the order of 20 MHz can be achieved. All four channels can be used for multidetector operation. The high count rate and the high number of channels make multimodule TCSPC systems exceptionally useful for diffuse optical tomography [34], and high count rate applications in laser scanning microscopy [39]. Details are described under Sect. 5.5, page 97 and Sect. 5.7, page 129. 

Applications of multiwavelength TCSPC to laser scanning microscopy have been demonstrated in [35, 60]. Spectrally resolved detection in diffuse optical tomography is described in [23]. A multianode MCP PMT and an SPC-330 TCSPC module were used to resolve the luminescence of alkali halides under N, Ar, Kr, and Xe ion irradiation [266]. 

K. D. Paulsen, Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue, Appl. Opt. 38, 5480-5490 (1999)... 

The book does not include data analysis. Analysis of multispectral TCSPC data, diffuse optical tomography data, or fluorescence correlation data differs considerably from traditional fluorescence decay analysis, and many analysis problems are not entirely solved yet. The author believes that data analysis should be the subject of a different book, and leaves this task to someone who is more familiar with it. 

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