Differentiation mechanism

These observations suggest differential mechanisms for the aggression-heightening effects of amphetamine as distinct from the disruptive actions on social and aggressive behavior. The neurobiological mechanisms for... 

Lendvai, B., Sershen, H., Lajtha, A. et al. Differential mechanisms involved in the effect of nicotinic agonists DMPP and lobeline to release [3H]5-HT from rat hippocampal slices. Neuropharmacology. 35 1769, 1996. 

Mizoguchi, H., Tseng, L. F., Suzuki, T., Sora, I. and Narita, M. Recent advances in the search for the p-opioidergic system differential mechanism of g-protein activation induced by endogenous p-opioid peptides, endomorphin and 5-endorphin. Jpn. J. Pharmacol. 89 239-244, 2002. 

Wang, Y.-H., Jones, D. R., Hall, S. D. Differential Mechanism-Based Inhibition of CYP3A4 and CYP3A5 by Verapamil. Drug Metab. Dispos. 2005, 33, 664—671. 

Figure 18.22. Differential mechanical analysis scans of polybenzoxazine. Reproduced from Ishida and Lee (2001), by permission of Elsevier, Ltd.

Koley AP, Buters JTM, Robinson RC, et al. Differential mechanisms of cyto-chrome-P450 inhibition and activation by alpha-naphthoflavone. J Biol Chem 1997 272 3149-3152. 

Chiral Host Type of Reaction Excitation Mode Differentiation Mechanism Reference... 

Media Chiral source Excitation mode Differentiation mechanism Chiral source/ substrate ratio Optical yield... 

Sawa, T., Mameya, S., Yoshimura, M., Itsuno, M., Makiyama, K., Niwa, M. Taniyama, K. (1995) Differential mechanism of peptide YY and neuropeptide Y in inhibiting motility of guinea pig colon. Eur.J. Pharmacol. 276, 223-230. 

Koley, A.P., J.T.M. Buters, R.C. Robinson, A. Markowitz, and FK. Friedman (1997). Differential mechanisms of cytochrome P450 inhibition and activation by a-naphthoflavone. J. Biot. Chem. 272, 3149-3152. 

Scheme 11-10 The cross-trimerization reactions employed for differentiating mechanisms A-C.

The role of these small molecules in the aortic valve is a relatively new frontier. miRNAs have been studied in the interstitial cells and two miRNAs have been found to play a role in the valve calcification process. MiRNA-30b has been found to be an inhibitor of osteoblast differentiation and its expression is reduced in stenotic valves compared to healthy valves [137]. Another mlRNA also studied in aortic valvular interstitial cells has been miRNA-141, this mlRNA reduces TGF-P activation, BMP-2 signaling and alkaline phosphatase activity and its expression is attenuated in bicuspid valves compared to tricuspid healthy valves [138]. Of note, several miRNAs have recently been reported to react specifically to differential mechanical shear stress (shear-sensitive miRNAs), indicating their potential importance in disturbed flow-mediated conditions such as atherosclerosis and aortic valve calcification. 

De Grandi, A.D. Calvari, V. Bertini, V. Bulfone, A. Peverali, G. Camerino, G. Borsani, G. Guioli, S. (2000). The expression pattern of a mouse doublesex-related gene is consistent with a role in gonadal differentiation. Mechanisms of Development, Vol.90, No.2, pp. 323-326, ISSN 0925-4773... 

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