Imbalanced diets

Fat is a key component in the human diet. Research shows that excessive consumption of saturated fat negatively impacts several biomarkers of health while monounsaturated and n-3 PUFAs are beneficial to human health. Moreover, research shows that imbalanced dietary ratios of n-6 n-3 may lead to various health complications as well as disease progression while increased n-3 levels impart prevention and health promoting effects (Burghardt et al., 2010 Goodstine et al., 2003 Simopoulos, 2002 Wan et al., 2010). The American Heart Association recommends eating fatty fish meals at least twice a week due to their promising health and especially cardiovascular benefits. Here, we review some of the health benefits of n-3 PUFAs, due in part to their anti-inflammatory effects in cancer, cardiovascular diseases (CVDs), obesity, and other metabolic disorders. 

Maize gluten meal is not a very suitable feed for poultry since it is of relatively low palatability and being very deficient in lysine has an imbalanced AA profile. However, it can be incorporated in broiler and layer diets as a source of natural yellow pigment since it is rich in xanthophyll pigments (up to 300mg/kg). Maize gluten meal may no longer be available or economic for feed use as it is used extensively as a natural weed-killer in horticulture. 

Rats show a dramatic and reliable reduction of food intake if they are pre-fed a low-protein basal diet and then offered a diet that is imbalanced in any of the essential amino acids (Leung and Rogers 1969). This anorectic response has been used by Hammer et al. (1990) to test serotonin3 receptor antagonists. 

IMBALANCED DIETS HAVE UNDESIRABLE SIDE EFFECTS... 

Imbalanced diets, lacking in certain nutrients, often have consequences that are evident through symptoms and diseases that develop in the body. We may temporarily need to resort to a special diet to restore balance and get rid of unwanted symptoms. For example, when there is excessive water in the system, we may require a low-salt diet to correct it. But we must carefully limit the length of time such diets are used or the body will shift into a different but equally undesirable and imbalanced condition. It is best to work with a nutritionist or doctor who knows foods in order to take care of chemical deficiency symptoms. 

Sensing lAA Deficiency with Diets Either Imbalanced or Devoid of an lAA. 255... 

Rogers and Leung, 1973, 1977). Adaptation can occur over time to an imbalanced diet, but as with severe... 

Aja SM, Barrett JA, Gietzen DW. 1999. CCK and 5-HT3 receptors cooperate in anorectic responses to amino acid imbalanced diets. Pharmacol Biochem Behav 62 487-491. 

Bellinger LL, Evans JF, TiUberg CM, Gietzen DW. 1999. Effects of dorsomedial hypothalamic nuclei lesions on intake of an imbalanced amino acid diet. Am J Physiol 277 R250-R262. 

Bellinger LL, Gietzen DW, Williams FE. 1993. Liver denervation, 5-HT3 receptor antagonist, and intake of imbalanced amino acid diet. Brain Res Bull 32 549-554. 

Bellinger LL, Williams FE, Rogers QR, Gietzen DW. 1996. Liver denervation attenuates the hypophagia produced by an imbalanced amino acid diet. Physiol Behav 59 925-929. 

Beverly JL, Gietzen DW, Rogers QR. 1990. Effect of dietary limiting amino acid in prepyriform cortex on food intake. Am J Physiol 259 R709-R715. (First demonstration that nanomoles of the limiting lAA injected into the APC restore feeding of lAA imbalanced diets)... 

Gietzen DW, Erecius LF, Rogers QR. 1998. Neurochemical changes after imbalanced diets suggest a brain circuit mediating anorectic responses to amino acid deficiency. J Nutr 128 771-781. 

Gietzen DW, Leung PMB, Castonguay TW, Hartman WJ, Rogers QR. 1986. Time course of food intake and plasma and brain amino acid concentrations in rats fed amino acid-imbalanced or-deficient diets. Interactions of the Chemical Senses with Nutrition. Rare MR, Brand JG, editors. Philadelphia Academic Press pp. 415-459. 

Koehnle TJ, Stephens AL, Gietzen DW. 2004b. Threonine imbalanced diet alters first meal microstructure in rats. Physiol Behav 81 15-21. 

Transfer ribonucleic acid charging in rat brain after consumption of amino acid-imbalanced diets. Nutr Neurosci 5 125-130,... 

The rapid anorectic response to a threonine imbalanced diet is decreased by injection of threonine into the anterior piriform cortex of rats. Nutr Neurosci 6 247-251. 

Cammarano, P., Chinali, G., Gaeteni, S., and Spandoni, M. A., Involvement of adrenal steroids in the changes of polysome organization during feeding of imbalanced amino acid diets, Biochim. Biophys. Acta, 155, 302, 1968. 

H7 Hashimoto, S. Effects of nucleic acid precursors on liver injuries. I. Treatment of liver injury induced by low protein, amino acid imbalanced diet with AICA and AICA orotate in massive doses. J. Vitaminol. 13, 9-18 (1976)... 

CAUTION It is not advisable for people to undertake on their own, without a physician s advice, to change the relative acidity or alkalinity of their body fluids and urine. Overemphasis of certain foods and avoidance of others may result in a deficient or imbalanced diet. 

Kwashiorkor. Infants fed low-protein, starchy foods (such as bananas, yams, and cassava) after weaning may develop kwashiorkor. This imbalanced diet, which has a subnormal protein-to-calorie ratio for infants, prevents some... 

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