Prepyriform cortex

Haberly LB, Shepherd GM. 1973. Current-density analysis of summed evoked potentials in opossum prepyriform cortex. J Neurophysiol 36 789-802. 

Westenbroek RE, Westrum LE, Hendrickson AE, Wu JY. 1987. Immunocytochemical localization of cholecystokinin and glutamic acid decarboxylase during normal development in the prepyriform cortex of rats. Brain Res 431 191 - 206. 

Beverly JL, Gietzen DW, Rogers QR. 1990. Effect of dietary limiting amino acid in prepyriform cortex on food intake. Am J Physiol 259 R709-R715. (First demonstration that nanomoles of the limiting lAA injected into the APC restore feeding of lAA imbalanced diets)... 

Leung PMB, Rogers QR. 1971. Importance of prepyriform cortex in food-intake response of rats to amino acids. Am J Physiol 221 929-935. (First report that anterior piriform cortex functions as a sensor for lAA deficiency)... 

Noda K, Chikamori K. 1976. Effect of ammonia via prepyriform cortex on regulation of food intake in the rat. Am J Physiol 231 1263-1266. 

Piriform cortex (Fig. 15 C-D 17 A-F), also referred to as pyriform or prepyriform cortex, is a phylogenetically old, paleocortical structure. PC is located along the entire length of the lateral olfactory tract at the ventrolateral convexity of the base of the cortex. PC is thicker and more elaborate caudally than it is rostrally. PC is allocortical, having only two-three cellular layers and is thinner and less complex than the neocortex which has six layers. Haberly and Price (1978b) divided the piriform cortex into 3 layers that are further subdivided on the basis of cytoarchitecture and afferent connections. 

Gale and colleagues (Halonen et al. 1994) have recently identified key relay sites involved in the spread of seizures triggered in deep prepyriform cortex to other forebrain structures. These studies found that microinjections of muscimol or non-NMDA receptor antagonists into posterior PC or the dorsally adjacent perirhinal cortex prevented the propagation of seizures from rostral PC. 

Turski, L., Cavalheiro, E.A., Calderazzo-Filho, L.S., et al, 1989. The basal ganglia, the deep prepyriform cortex, and seizure spread bicuculline is anticonvulsant in the rat striatum. Proc. Natl. Acad. Sci. USA 86, 1694-1697. 

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