2-diethylamino-N-

Therapeutic Function Local anesthetic, antiarrhythmic Chemical Name 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Common Name Lignocaine... 

SYNS ANESTACON HYDROCHLORIDE 2-piETHYLAMINO)-2, 6 -ACETOXYLIDIDE MONOHYDROCHLORIDE a-DIETHYLAi IINO-2,5-ACETOXYLIDINE HYDROCHLORIDE 0)-DIETHYLAMINO-2,6-DIMETHYLACETANILIDE HYDROCHLORIDE 2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ACETAi IIDE MONOHYDROCHLORIDE DUNCAINE HYDROCHLORIDE GRAVOCAIN HYDROCHLORIDE ISICAINE HYDROCHLORIDE LEOSTESIN HYDROCHLORIDE... 

Lida-Mantle Xilina Xllina 2-(diethylamino)-N-(2,6-dimethylphenyl)-Acetamide Xyloneural Cappicaine a-(Diethylamino)-2,6-acetoxylidide Duncaine Gravocain Isicaina Isicaine Leostesin Lignocaine Maricaine Xycaine Xylestesin Xylo-cain Xylocaine Xylocitin Xylotox 2-(Diethylami-no)-2, 6 -acetoxylidide Diethylaminoaceto-2,6-... 

Lidocaine [2-(diethylamino)-N-(2, 6-dimethylphenyl) acetamide monohydrochloride] is the most commonly used amino amide-type local anesthetic. Lidocaine is very lipid soluble and, thus, has a more rapid onset and a longer duration of action than most amino ester-type local anesthetics, such as procaine and tetracaine. It can be administered parenterally (with or without epinephrine) or topically either by itself or in combination with prilocaine or etidocaine as a eutectic mixture that is very popular with pediatric patients. The use of lidocaine-epinephrine mixtures should be avoided, however, in areas with limited vascular supply to prevent tissue necrosis. Lidocaine also frequently is used as a class IB antiarrhythmic agent for the treatment of ventricular arrhythmias, both because it binds and inhibits sodium channels in the cardiac muscle and because of its longer duration of action than amino ester-type local anesthetics. 

Lidocaine 2-(Diethylamino)-N-(2,6-dimethyl-phenyl)acetamide Lignocaine, Xylocaine... 

The quaternization of pyrazine compounds has not been extensively studied, and, therefore, a detailed discussion of the effect of substituents is not possible. Recently Cheeseman has shown, from spectroscopic evidence, that 2-amino- and 2-diethylamino-pyrazine (50, Y = NH2 and NEt2) quatemize at N-4, although protonation occurs at position-1. Other substituted pyrazines from which quaternary salts of structure 51 are formed include 2-chloro- and 2-... 

Chemical Name Equimolar mixture of Clofexamide which is 2-(p-chlorophenoxy)-N-[2-(diethylamino)Bthyl] acetamide with phenylbutazone... 

There was obtained a mixture of N-(2 -diethylamino-2 -methylethyl)phenthiazine and N-(2 -diethylamino-1 -methylethyDphenthiazine in the form of a viscous yellow oil, BP 202° to 205°C/2 mm. This oil was treated in ethereal solution with ethereal hydrogen chloride and gave a white solid which was fractionally crystallized from ethylene dichloride. The less soluble fraction, N-(2 -diethylamino-2 -methylethyl)phenthiazine hydrochloride formed colorless rhombs, MP 223° to 225°C. The more soluble N-(2 -diethylamino-1 -methylethyl)-phenthiazine hydrochloride was obtained as colorless prismatic needles, MP 166° to 168°C. 

Chemical Name 2-(4-butoxyphenoxy)-N-(2,5-diethoxyphenyl)-N-[2-(diethylamino)ethyl] -acetamide... 

Chemical Name 6 -(8enzoylamino)-4-[2-(diethylamino)ethoxy] -N,N-dipropylbenzenepro-panamlde... 

N, A,-Diethyl-5-phenyl-3//-azcpin-2-amine (4) with a variety of bases yields the intensely colored (black-violet) 8 7t-antiaromatic 2-(diethylamino)-5-phenylazcpinyl anion, which can be captured by a range of electrophilic reagents as the 3-substituted 3//-azepines, e.g. 16-18.38... 

In fact, the stereochemistry of the hydroamination seems to depend strongly on the experimental conditions. For example, for the condensation of Et2NH with 1,3-butadiene, either cis-l-diethylamino-2-butene (n-BuLi, CgHs-EtjO) [204, 205], or trans-l-diethylamino-2-butene (sec-BuLi, THF) [155] can be obtained in ca. 98% yield stereoselectivity. In some cases, telomerization products are also formed [205]. 

C19H31N207+ C1- H20 2-(Diethylamino)ethyl 4-(/ -D-glucopyranosyl-amino)benzoate, monohydrate (N-/ -D-glucopyranosylprocaine, monohydrate) (PRCGLS)104... 

N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropyl-N-methylpropan-2-aminium Iodide N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropylpropan-2-aminium Chloride N-(2-Chloroethyl)dimethylamine N-(2-Chloroethyl)-N,N-dimethylamine N-(2-Hydroxyethyl)diethylamine N-(4-Oxy-3-methoxybenzyl)-8-methyl-6-nonenamide N-(Diethylamino)ethanol N-(Isopropyl)-2-propamine... 

Nitro(imidoyl)ketene PhN=C(NEt2)C(N02)=C0 eliminates C02 on heating and rearranges to 2-diethylamino-3-hydroximino-3// -indole 14, presumably via nitrile oxide PhN=C(NEt2)C-N+O-(90). 

Anders, M.W. and Mannering, G.J. Kinetics of the inhibition of the N-demethylation of ethylmorphine by 2-diethylamino-ethyl 2,2-diphenyl valerate HC1 (SKF-525A) and related compounds. Mol. Pharmacol. (1966) 2 319-327. 

Schwesingefs phosphazene base 2-tert-butylamino-2-diethylamino-l,3-dimethyl-perhydro-l,3,2-diazaphosphorine (PS-BEMP has a pKb = 27.5 in MeCN) has been immobilized and shown to have immense utility in the N- and O-alkylation of many weakly acidic heterocycles. Kim et al. has made extensive use of this reagent in the multi-step synthesis of a small collection of guanines possessing potential antiviral activity [90]. The generic procedure involved the direct alkylation of the purine moiety (20) (Scheme 2.64), promoted by PS-BEMP, resulting in a mixture... 

Procainamide Procainamide, 4-amino-N-[2-(diethylamino)ethyl]benzamide (18.1.3), is synthesized by reacting 4-nitrobenzoic acid chloride with N,N-diethylethylendiamine and subsequent reduction of the nitro gronp of the resnlting 4-nitro-N-[2-(diethylamino)ethyl]ben-zamide (18.1.2) into an amino group [8,9]. 

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