Dietary studies, weight gain reductions

For dietary smdies, weight gain reductions are considered in the context of whether there may be an issue of palatability. In the case of inhalation studies with respirable particles, evidence of impairment of normal clearance of particles from the Inng shonld be considered along with other signs of toxicity to the respiratory airways to determine whether the high exposure concentration has been appropriately selected (EPA 2001). For dermal studies, evidence of skin irritation may indicate that an adeqnate high dose has been reached (EPA 1989). 

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