Phenytoin Dicoumarol

Dicoumarol Phenytoin Phenylbutazone Salicylic Acid Tobutamide... 

Among drugs considered to be absorbed more quickly with food are carbamazepine, phenytoin, diazepam, dicoumarol, erythromycin (contentious), griseofulvin, hydralazine, hydrochlorothiazide, lithium citrate, labetalol, propranolol, metoprolol, nitrofurantoin, propoxyphene and spironolactone,... 

Codeine Hydrochloride Dequalinium Acetate Fluorometholone Hexamethonium Bromide Riboflavine Stilbazium Iodide Mianserin Hydrochloride Tacrine Hydrochloride Diclofenac Sodium Vinblastine Sulphate Cyclizine Hydrochloride Amiloride Hydrochloride Protoveratrine B Meclofenamate Sodium 5-Methyltryptamine Hydrochloride Dicoumarol Mebendazole Pipradrol Hydrochloride Carbenoxolone Flucytosine Phanquone Phenytoin... 

Dicoumarol Phenobarbital Phenytoin Risk of toxicity, particularly with phenytoin Inhibition of metabolism of the object drugs... 

Phenytoin 300 mg daily was given to 6 subjects taking dicoumarol 40 to 160 mg daily for a week. No significant changes in the prothrombin-pro-... 

A study in 6 subjects taking phenytoin 300 mg daily found that when they were also given dicoumarol (doses adjusted to give prothrombin values of about 30%) their serum phenytoin levels rose on average by almost 10 micrograms/mL (126%) over 7 days. In another study the half-life of phenytoin in 3 patients increased by about frvefold during dicoumarol treatment. ... 

A patient taking dicoumarol developed phenytoin toxicity within a few days of starting to take phenytoin 300 mg daily (dose based on a weight of 62 kg). Phenytoin was withdrawn, and re-introduced at 200 mg daily, which gave satisfactory phenytoin levels. ... 

None of these interaetions has been extensively studied nor are they well established, but what is known suggests that the use of dicoumarol with phenytoin should be avoided or monitored very closely. Serum phenytoin levels and anticoagulant control should be well monitored if acenoeou-marol, phenprocoumon or warfarin is given with phenytoin. Dosage adjustments may be needed to accommodate any interactions. Information about other anticoagulants (apart from phenindione, which had no effect... 

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