Diclofenac release mechanism

Similarly, the introduction of sodium methacrylate into the polymeric network instead of NlPAAm carried out to the formation of a pH responsive hydrogels with high biocompatibility by virtue of the use of sunflower seed oil containing different amounts of lecithin as continuous phase in the eco-friendly emulsion polymerization (Curcio et al., 2013). The hydrogels was proposed as delivery system for the diclofenac sodium salt resulting in a predominant diffusional release mechanism. 

Miyagawa, Sato, and coworkers studied the controlled-release and mechanism of release of diclofenac in studies conducted in 1996 and 1997. These researchers utilized a twin-screw compoimding extruder... 

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