Dichloroethylenediamine platinum

The closely related dichloroethylenediamine platinum(II) was found to be slightly better than PtCll- as a heavy atom. A platinum-sulphur bond to methionine 29 is formed according to current analysis (now confirmed). The platinum cannot be removed by washing the crystal in sharp contrast to the reversible binding of other metal complexes. ... 

The differences revealed in the gel electrophoretic pattern of the nucleosome core particle after binding cis- and trans-DPP (10) could possibly provide a simple in vitro screen for pTatinum antitumor drug activity. Preliminary studies (12) have shown that nucleosome cores incubated with either dichloroethylenediamine-platinum(II) or cis-dichlorobis(isopropylamine)-platinum(II), two known antitumor drugs, exhibit gel electrophoretic patterns very similar to those of nucleosome cores incubated with cis-DDP. Incubation with [(terpy)PtCl]Cl, an inactive compound, gave very different gel patterns. Further work is in progress to evaluate the utility of this assay. 

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See also in sourсe #XX -- [ ]

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