Neutropenia diazoxide

Hematologic Bone marrow suppression leading to anemia and febrile neutropenia has been reported in an adolescent who was given high doses of diazoxide for hyperinsulinemic hypoglycemia [102" ]. The cause of the underlying condition was eventually discovered to be Munchausen syndrome by proxy. 

Multioi an damage An infant with persistent hyperinsulinemic hypoglycemia received diazoxide and developed pulmonary hypertension, heart failure, and neutropenia [119 ]. 

A girl with macrosomia, who was deUvered by cesarean section at 34 weeks, developed seizures and hypoglycemia in the first days of Ufe due to hyperinsuhnemia and was given octreotide and diazoxide. After 10 days she became short of breath with signs of heart failure and had evidence of pulmonary hypertension on echocardiography and cardiac catheterization. There was also neutropenia. Her respiratory... 

Yildizdas D, Erdem S, Kucukosmanoglu O, Yilmaz M, Yuksel B. Pulmonary h5fpertension, heart failure and neutropenia due to diazoxide therapy. Adv Ther 2008 25(5) 515-9. 

Side effects which follow the intravenous injection of diazoxide also include peculiar taste sensations, nausea and vomiting after the injection, abdominal pain or low back pain and constipation. A burning sensation along the vein into which the drug is injected is often mentioned extravasation may lead to tissue necrosis and can cause extreme pain (105, 106, nos IIF). Haematological reactions include neutropenia, thrombocytopenia and eosinophilia (I05 ). Episodes of haemolysis concurrent with the use of diazoxide over several days were observed in a 26-year-old Nigerian male with severe hypertension and impaired renal function (112 ),... 

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