Diazepine formation

No benzodiazepine has been obtained from o-phenylenediamine and 3,3-dimethylpentane-2,4-dione (38MI1 40MI1, 40MI2 63JA3354 75TL91) a monoacylated 2,3-diaminophenazine formed by self-condensation of two molecules of the diamine and subsequent reaction with the diketone has been isolated from the reaction mixture. It is possible that diazepine formation requires the presence of some enol form of a diketone. 

Diazepines, formation from N-imides of cyclic amines 83YZ373. 

Diazepines. - Formation. The full papers have now been published on the thermal isomerization of 17f-l,2-diazepines (76) to the fully unsaturated H-... 

Diazepines.—Formation. The acid-catalysed reaction of some aj8,y5-unsat-urated ketones (43) with tosylhydrazine provides an easy route to 3,4-dihydro-... 

Diazepines.—Formation. There is a report on the formation of the C=N bond in l,4-benzodiazepin-2-ones and in l,2-dihydropyrazin-2-ones by the intramolecular reaction of aldehyde groups or keto-groups with iminophos-phoranes the process had earlier been described in the patent literature. 1,4-Benzodiazepin-2-ones have also been prepared from indoles by ozonolysis followed by reductive cyclization with hydrazine hydrate. A new simple syn-... 

H. Sawanishi, T. Tsuehiya, Regioselective diazepine formation from 3-azidopyridines, Chem. Pharm. Bull., 1985, 33, 5603-5605. 

Diazepines - Formation.- The promise of biological activity, and its refinement, continues to act as the spur to synthetic endeavours in this area. A new preparation of the... 

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