Papaverine Diazepam

Cyclic AMP phosphodiesterase inhibitors, with or without an appropriate agonist are also candidates for clinical experimentation. In preliminary work, which requires confirmation, we have reported greater low Km cyclic AMP phosphodiesterase activity in psoriatic lesions than in normal appearing areas in six patients. If this is the case in an in vivo lesion and is not an artifact of tissue preparation for biochemical analysis, a cyclic AMP phosphodiesterase inhibitor may be an excellent choice. We have shown that epidermal cyclic AMP phosphodiesterase is inhibited by caffeine, theophylline, diazepam, papaverine and R020-1724. The methyl xanthines are poor inhibitors, whereas papaverine and R020-1724 are potent... 

Edder et al. reported the capillary supercritical fluid chromatography of basic drugs of abuse, namely nicotine, caffeine, methadone, cocaine, imipramine, codeine, diazepam, morphine, benzoylecgonine, papverine, narcotine, and strychnine [25]. They compared the separation of these drugs on DBS and DB wax columns. The chromatographic conditions included a carbon dioxide mobile phase and a flame-ionization detector. It was noted that on the DBS column, all peaks other than methadone and cocaine were separated. With the exception of benzoylecgonine and papaverine, all other peaks were separated on a DB wax column. A reproducibility of less than 5% was obtained with an internal standard method. The detection limits obtained were within 10-50 ppm on both the columns. A linearity of >0.99 was obtained for methadone, codeine, and morphine in the concentration range 10-1000 ppm. 

Those agents that interact with calcium channels but have another primary site of action include agents acting on sodium channels (local anesthetics and phenytoin), catecholamine receptors (benextramine, nicergoline, phenoxy-benzamine, phenothiazines, pimozide, propranolol, and yohimbine derivatives), benzodiazepine receptors (diazepam and flurazepam), opiate receptors (loperamide and flu-peramide), and cyclic nucleotide phosphodiesterases (amrinone, cromoglycate, and papaverine), as well as barbiturates, cyproheptadine, indomethacin, and reserpine. 

Hays, P.A. Lurie, I.S. Quantitative analysis of adulterants in illicit heroin samples via reversed phase HPLC. J.Liq.Chromatogr., 1991, 14, 3513—3517 [also acetylcodeine, acetylmorphine, aspirin, ben-zocaine, caffeine, chloroquine, diamorphine, diazepam, diphenhydramine, dip3rrone, lidocaine, meth-aqualone, monoacetylmorphine, morphine, nicotinamide, noscapine, papaverine, phenacetin, pheno-barbital, phenolphthalein, N-phenyl-2-naphthylamine, salicylic acid, strychnine]... 

Noninterfering diazepam, etomidate, fentanyl, heparin, pancuronium, papaverine, poly-geline, procaine, protamine, sodium nitroprusside... 

Extracted buprenorphine, caffeine, cocaine, diamorphine, ethylmorphine, lidocaine, meth-aqualone, morphine, naloxone, noscapine, papaverine, pentazocine, procaine Also analyzed bromazepam, clonazepam, diazepam, flunitrazepeun, flurazepam, medaze-pam, nitreizepam, oxetzepam... 

Noninterfering aspirin, caffeine, chlordiazepoxide, dextropropoxyphene, diazepam, lig-nocaine, naloxone, norcodeine, normorphine, papaverine, procaine, quinine, theobromine, theophylline... 

Lurie, I.S. McGuiness, K. The quantitation of heroin and selected basic impurities via reversed phase HPLC. II. The analysis of adulterated samples. J.Liq.Chromatogn, 1987, 10, 2189-2204 [UV detection electrochemical detection also acetaminophen, acetylcodeine, acetylmorphine, acetylprocaine, aminopyrene, amitriptyline, antipyrine, aspirin, barhital, benztropine, caffeine, coceiine, diamor-phine, diazepam, diphenhydramine, dipsrone, ephedrine, ethylmorphine, lidocaine, meconin, meth-amphetamine, methap3rrilene, methaqualone, morphine, nalorphine, niacinamide, noscapine, papaverine, phenacetin, phenmetrazine, phenobarbital, phenolphthalein, procaine, propanophenone, propoxyphene, pyrilamine, quinidine, quinine, salicylamide, saliqrlic acid, secobarbital, strychnine, tartaric acid, tetracaine, thebaine, tripelennamine, tropacocaine, vitamin B3, vitamin B5]... 

Also analyzed acetaminophen, acetylcodeine, acetylmorphine, aminopyrene, aminopyrine, amobarbital, amphetamine, antipyrine, benzocaine, butabarbital, caffeine, cocaine, codeine, diamorphine, diazepam, diethylpropion, DMT, ephedrine, glutethimide, Lampa, lidocaine, LSD, MDA, mecloqualone, mescaline, methamphetamine, methapyrilene, meth-aqualone, methpyrilene, morphine, narcotine, papaverine, PCP, pentobarbital, phencyclidine, phendimetrazine, phenmetrazine, phenobarbital, phentermine, phenylpropeinolam-ine, procaine, quinidine, quinine, secobarbital, strychnine, TCP, tetracaine, thebaine, theophylline... 

Noninterfering amitriptyline, amphetamine, atropine, benzoylecgonine, benztropine, caffeine, carbamazepine, carisoprodol, chlorpheniramine, chlorpromazine, chlorprothixene, cimetidine, cocaine, codeine, dextromethorphan, diazepam, diphenhydramine, diphenox-ilate, disopyramide, doxepin, dojylamine, emetine, erythromycin, flurazepam, gluteth-imide, hydrocortisone, hydromorphone, hydroxyzine, imipramine, lidocaine, loxapine, meperidine, meprobamate, methadone, methamphetamine, methapyrilene, methaqualone, methocarbamol, methylphenidate, nicotine, nordiazepam, nortriptyline, orphenadrine, papaverine, pentazocine, phenacetin, phencyclidine, phenmetrazine, phenolphthalein, phentermine, phenylpropanolamine, phenytoin, prazepam, procaineimide, procaine, propoxyphene, propranolol, protriptyline, pseudoephediine, pyrilamine, quinine, salicylam-ide, spironolactone, strychnine, terpin hydrate, thioridazine, thiothixene, triamterene, trifluoperazine, triflupromeizine, trihexyphenidyl, trimeprazine, trimethobenzamide, trimethoprim, tripeleimamine... 

---