Diazepam apnea with

Older or debilitated adults may require a reduced dosage of diazepam to reduce ataxia and oversedation. The nurse observesthese patients carefully. Apnea and cardiac arrest have occurred when diazepam is administered to older adults very ill patients and individuals with limited pulmonary reserve. 

Use with caution in oider patients with Concurrent treatment with potent CYP 3A4 inhibitors (e.g., nefazodone) leads to increased plasma concentrations of diazepam COPD untreated sleep apnea... 

Adverse CNS effects occur when the procaine portion of the procaine benzylpenicillin (procaine penicillin) formulation is given intravascularly. The signs of toxicity include hyperexcitability, muscle tremors, ataxia, apnea and cardiac arrest. There is no specific treatment for procaine toxicity one can only attempt to prevent the horse from injuring itself and others imtil the effects of the procaine wear off. The CNS reaction can be prevented by pretreatment with diazepam. The solubility of the procaine fraction of procaine benzylpenicillin (procaine penicillin) formulations increases with increasing ambient temperature, so these products should be stored in a cool place to reduce the risk of reactions. Procaine is a common cause of positive drug tests in racehorses and other performance horses. Procaine benzylpenicillin (procaine penicillin) should be avoided in these animals. 

C. Chloroquine and hydroxychloroquine intoxication. There is reported improvement of cardiotoxicity with high-dose administration of diazepam at 1-2 mg/kg IV (infuse over 30 minutes) followed by an infusion of 2 mg/kg/24 hours. Caution This will likely cause apnea the patient must be intubated, and ventilation must be controlled. 

Patients with severe symptoms (seizing, apnea, cyanosis, unconsciousness) should immediately receive three NAAKs plus diazepam (CANA injector). The autoinjectors will work through two layers of clothes or a chemical suit. 

---