Diatrizoate adverse reactions

Extravasation of barium sulfate iato the peritoneal cavity through a perforated GI tract can produce serious adverse reactions. When a perforation is suspected, the use of a water-soluble iodinated contrast medium is iadicated. In this case, oral or rectal administration of sodium or meglumine-sodium salts of diatrizoic acid (6) and oral use ofiohexol (11) are the preferred procedures. 

Urine iodine concentration, after the injection of nonionic metrizamide. is about twice as high as after sodium diatrizoate injection. Gol-man et al. (795) reported that during the periods of ureteric stasis, metrizamide was excreted faster than diatrizoate. Nonionic iopamidol reduces the incidence of adverse reactions in excretory urography and produces equal quality urograms with less iodine than diatrizoate (881). 

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