Toxicogenomics diagnostic

A review of case studies in the use of toxicogenomics in drug discovery reveals three main categories of application diagnostic toxicogenomics (biomarkers), predictive toxicogenomics, and mechanistic/investigative studies (Searfoss et al., 2005, Khor et al., 2006, Chen et al., 2012). In this... 

While diagnostic toxicogenomic biomarkers show great promise and utility in these types of proof-of-concept studies, translatability to routine use in the drug discovery testing paradigm or application to human health has not yet become mainstream. 

Another example of the use of toxicogenomic data for diagnostic purposes is identification of expression changes correlating with drug-induced renal tubular toxicity in rats... 

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