Case Studies Diagnostic Toxicogenomics

Another example of the use of toxicogenomic data for diagnostic purposes is identification of expression changes correlating with drug-induced renal tubular toxicity in rats 

While diagnostic toxicogenomic biomarkers show great promise and utility in these types of proof-of-concept studies, translatability to routine use in the drug discovery testing paradigm or application to human health has not yet become mainstream. 

---

A review of case studies in the use of toxicogenomics in drug discovery reveals three main categories of application diagnostic toxicogenomics (biomarkers), predictive toxicogenomics, and mechanistic/investigative studies (Searfoss et al., 2005, Khor et al., 2006, Chen et al., 2012). In this... 

---