Diabetogenic effect

Diabetogenic effect. Chromatographic fraction of the fresh stem, administered intragastrically to rats at a dose of 1 g/kg, was active. The fraction inhibited the elevation of semm TG, lipid peroxides, and insulin of rats fed on a high-sugar diet for 61 days . 

Ahren B, Adner N, Svartberg J, Petrella E, Holst JJ, Gutniak MK. Anti-diabetogenic effect of the human amylin analogue, pramlintide, in Type 1 diabetes is not mediated by GLP-1. Diabet Med 2002 19(9) 790-2. 

Prolonged administration of nicotinic acid can have a diabetogenic effect and decompensation of previously stable diabetes can occur. Severe hyperglycemia has been precipitated by nicotinic acid treatment of hyperlipidemia (24). 

Dehydroascorbic acid appears to have a diabetogenic effect and ascorbic acid causes increased excretion of glucose. High ascorbic acid concentrations can delay the insulin response to a glucose challenge and prolong postprandial hyperglycemia (170). 

Panz VR, Bonegio R, Raal FJ, Maher H, Hsu HC, Joffe BI. Diabetogenic effect of tacrolimus in South African patients undergoing kidney transplantation. Transplantation 2002 73(4) 587-90. 

In vitro GH has been shown to stimulate glucose uptake and utilization in several tissues, including diaphragm and adipose tissue [41,90]. Diabetogenic effects of the hormone are more difficult to demonstrate in vitro, although some such effects have been obtained [90]. 

While GH is essential in this respect, the diabetogenic effect of cortisol is evident only in conjunction with GH (Kollind et al., 1987). Insulin resistance occurs for at least 12 hours after hypoglycaemic episodes in patients with IDDM. Adrenaline causes immediate insulin resistance, whereas GH exerts a sustained resistance only after a lag period of about 4 hours (Kollind, 1988). 

Soto-Blanco, B., Sousa, B., Manzano, J.L., Guerra, J.L., and Gomiak, L., Does prolonged cyanide exposure have a diabetogenic effect Vet. Hum. Toxicol, 43, 106-108, 2001. 

Bhatnagar SK, AminlvflvIA, Al-Yusuf AR. Diabetogenic effects of nifedipine. BM/(1984) 289,19. 

Heyman SN, Heyman A, Halperin I. Diabetogenic effect of nifedipine. DICP Ann Pharma-coiher 9Z9)22,236-7. 

Because of the significance of such results, several laboratories tried to repeat this work, and, although it could be demonstrated that an anterior pituitary extract inhibits hexokinase, it soon became clear that this effect on hexokinase and the diabetogenic effect of the pituitary hormone are unrelated. 

When pituitary extracts with a powerful diabetogenic effect were used, the inhibition of hexokinase and the relief of the inhibitory effect by insulin were found to be very irregular. Furthermore, many of the... 

It is not yet clear whether the combination of statin and niacin will increase the incidence of diabetes. This is of significance as recent meta-analysis has shown that the association of incidence of diabetes with statin therapy remains uncertain. In particular the authors of the meta-analysis recommended that future statin trials should be designed to investigate whether statin treatment is associated with increased risk of induced diabetes (Rajpathak et al. 2009). Evaluation of the longer term impact of niacin s effect on insulin resistance and glucose metabolism awaits the results of longer-term clinical trials. Perhaps this may elicit or refute the diabetogenic effect of niacin. 

Patterson, J. W., 1950, The diabetogenic effect of dehydroascorbic acid and dehydroisoascorbic acid, J. Biol. Chem. 183 81-88. 

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