Diabetes mellitus type secondary failure

Ross SA, Zinman B, Campos RV, Stack T. A comparative study of insulin lispro and human regular insulin in patients with type 2 diabetes mellitus and secondary failure of oral hypoglycemic agents. Clin Invest Med 2001 24(6) 292-298. 

Diabetes mellitus (DM) is an example of an endocrine disorder it is the most common endocrine disorder in the United States (see Chapter 25). It is classified as either type 1 or type 2. DM type 1 results from a failure of the pancreas to secrete insulin even though the pancreas is otherwise normal. Type 2 is the most common form of DM and results from end-organ resistance to the action of insulin that, in this case, is secreted from the pancreas in abundant amounts and circulates at high concentrations. Secondary DM occurs when a nonendocrine disease, such as pancreatitis, destroys the pancreas including the insulin secreting cells. The biochemical hallmark of DM is hyperglycemia. 

And what happens with diabetes mellitus In 525 Caucasian type 2 diabetic patients, the common E23K variant of KCNJll encoding the pancreatic P-cell adenosine 5 -triphosphate-sensitive potassium channel subunit Kir6.2 was associated with increased risk for secondary failure to treatment with sulfonylurea-like glibenclamide [106]. 

Levy J, Atkinson AB, Bell PM, McCance DR, Hadden DR. Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus the 10-year follow-up of the Belfast Diet Study. Diabet Med 1998 15 290-296. 

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