Diabetes chelate complexes

Ascorbic acid also forms soluble chelate complexes with iron (142—145). It seems ascorbic acid has no effect on high iron levels found in people with iron overload (146). It is well known, in fact, that ascorbic acid in the presence of iron can exhibit either prooxidant or antioxidant effects, depending on the concentration used (147). The combination of citric acid and ascorbic acid may enhance the iron load in aging populations. Iron overload may be the most important common etiologic factor in the development of heart disease, cancer, diabetes, osteoporosis, arthritis, and possibly other disorders. The synergistic combination of citric acid and ascorbic acid needs further study, particularly because the iron overload produced may be correctable (147). 

Vanadium Compounds Used for Treatment of Diabetes Salts, Chelate Complexes, and Peroxovanadium Compounds... 

Loweth et al. [120] showed that fluoride induces apoptosis in clonal pancreatic fi cells and in the cells of normal rat islets of Langerhans. The process may reflect the formation of AlF41 since it was inhibited by the aluminum chelator desferrioxamine. Recent studies provide evidence that apoptosis of pancreatic fi cells is important in the early etiology of diabetes mellitus. Treating thymus lobe cells with aluminofluoride complexes also provoked apoptosis of a wider range of thymocyte subtypes [121] with an accumulation of inositol phosphates. The responses to aluminofluoride complexes were not prevented by inhibitors of tyrosine kinases, suggesting that unidentified G-proteins which couple to phospholipase C activation may also be capable of initiating apoptosis by a route independent of the T cell receptor. 

A number of zinc compounds and complexes have been developed for therapeutic purposes. Several zinc complexes of cyclam-based ligands have proved potent inhibitors of HIV, while hydroxypyridinone complexes are being assessed as insulin mimics for the treatment of diabetes. There is some evidence that the administration of certain zinc chelates may help to ward off strokes, while a suberoylanihde hydroxamate complex has been in clinical trials as an anticancer agent since 2000. 

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