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Deuterium, H/D exchange

Study of conformational changes by hydrogen-deuterium (H-D) exchange... [Pg.315]

This mechanistic proposal has extensive experimental support Imine 16 has been trapped and localized, and enzyme-catalyzed hydrogen/deuterium (H/D) exchange at C3 and C4 of DXP as well as carbonyl oxygen exchange has been detected. Acyl transfer to the C4 hydroxyl (18 to 19) as well as transfer of oxygen from DXP to nascent ThiS-COOH (21 to 22) has been demonstrated. Intermediate 22 has been trapped and detected by mass spectrometric analysis and the reaction product 14 has been fully characterized. Thiazole synthase complexed with ThiS-COOH has been structurally characterized and the DXP imine 16 has been modeled into the active site revealing key catalytic residues. ... [Pg.550]

See other pages where Deuterium, H/D exchange is mentioned: [Pg.442]    [Pg.69]    [Pg.549]    [Pg.149]    [Pg.61]    [Pg.161]    [Pg.341]    [Pg.377]    [Pg.74]    [Pg.99]    [Pg.381]    [Pg.62]    [Pg.297]    [Pg.145]    [Pg.8]    [Pg.33]    [Pg.57]    [Pg.187]    [Pg.192]    [Pg.274]    [Pg.248]    [Pg.311]    [Pg.1279]    [Pg.1660]    [Pg.270]    [Pg.455]    [Pg.53]    [Pg.99]    [Pg.6]    [Pg.248]    [Pg.205]    [Pg.11]    [Pg.341]    [Pg.176]    [Pg.542]    [Pg.110]    [Pg.36]   
See also in sourсe #XX -- [ Pg.43 ]



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Deuterium exchange

Deuterium, exchanged

H-D exchange

H-exchange

Hydrogen/deuterium (H/D exchange

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