Deuterium bromide fluoride

Further acceleration of isotope exchange, by three to four powers of ten, can be achieved116-118 by working in liquid deuterium fluoride, particularly if it contains BF3.108-110 The properties attaching to deuterium bromide apply also to this system. For toluene, equilibrium is reached in 15 minutes,108 and, as in exchange in DBr, only the hydrogen atoms attached directly to the aromatic ring are replaced, even in presence of BF3. 

Other theoretical studies discussed above include investigations of the potential energy profiles of 18 gas-phase identity S 2 reactions of methyl substrates using G2 quantum-chemical calculations," the transition structures, and secondary a-deuterium and solvent KIEs for the S 2 reaction between microsolvated fluoride ion and methyl halides,66 the S 2 reaction between ethylene oxide and guanine,37 the complexes formed between BF3 and MeOH, HOAc, dimethyl ether, diethyl ether, and ethylene oxide,38 the testing of a new nucleophilicity scale,98 the potential energy surfaces for the Sn2 reactions at carbon, silicon, and phosphorus,74 and a natural bond orbital-based CI/MP through-space/bond interaction analysis of the S 2 reaction between allyl bromide and ammonia.17... 

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