Determination of maximum additive concentration

The maximum amount of solubilisate that can be incorporated into a given system at a fixed 

Solubility data are expressed as a solubility-concentration curve or as phase diagrams. The latter are preferable since a three-component phase diagram completely describes the effect of varying all three components of the system - namely, the soluhilisate, the solubiliser and the solvent. The axes of the phase diagram form an equilateral triangle (see Fig. 6.37), each side of which is divided into 100 parts to correspond to percentage composition. 

A typical phase diagram of a solubilised system is shown in Fig. 6.38. In solutions of high water content the oil is solubilised in 

The site of solubilisation within the micelle is closely related to the chemical nature of the soluhilisate (see Fig. 6.39). It is generally accepted that nonpolar solubilisates (aliphatic hydrocarbons, for example) are dissolved in the hydrocarbon core of ionic and nonionic micelles. Water-insoluble compounds containing polar groups are orientated with the polar group at the core/surface interface of the 

Hgure 6.38 Partial phase diagram for the Brij 97 (CigHjj (OCH2CH2)ioOH)-water-mineral oil solubilised system. 

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