Ritonavir Desipramine

Drugs that might be affected by lopinavir/ritonavir include ergot derivatives, oral contraceptives, antiarrhythmics, HMG-CoA reductase inhibitors, HIV protease inhibitors, atovaquone, calcium channel blockers, ketoconazole, itraconazole, pimozide, cisapride, clarithromycin, disulfiram, metronidazole, immunosuppressants, midazolam, triazolam, narcotic analgesics, rifabutin and rifabutin metabolite, sildenafil, warfarin, bupropion, clozapine, desipramine, piroxicam, quinidine, theophylline, and zolpidem. 

Clinically important, potentially hazardous interactions with amiodarone, amitriptyline, amoxapine, benzodiazepines, bepridil, clomipramine, clonazepam, clorazepate, delavirdine, desipramine, diazepam, dihydroergotamine, doxepin, ergotamine, fentanyl, flurazepam, imipramine, ixabepilone, lidocaine, lorazepam, methysergide, midazolam, nortriptyline, oxazepam, phenytoin, protriptyline, quazepam, quinidine, rifampin, ritonavir, sildenafil, St John s wort, temazepam, tricyclic antidepressants, trimipramine, vitamin E... 

Octi Acyclovir, AZT, ganciclovir, indinavir, ritonavir, nelfinavir, saquinavir, amantandine, desipramine, nicotine, procainamide, vecuronium, cimetidine, clonidine, prazosin, reserpine, verapamil... 

Ajmaline, alprenolol, amiflamine, amphetamine, aprindine, captopril, chlorpheniramine, cinnarizine, citalopram, clomipramine, clozapine, codeine, desipramine, dolasteron, encainide, flecainide, fluoxetine, fluphenazine, haloperidol, hydrocordone, imipramine, loratidine, methoxyphenamine, 3,4-methylenedioxymethamphetamine, metoprolol, mexiletine, (S)- and (i )-mianserin, nifedipine, olanzapine, omeprazole, oxycodone, perhexiline, phenformin, propaphenone, propranolol, remoxipride, ritonavir, saquinavir, selegiline, tamsulosin, timolol, tomoxetine, tramadol, trifluperidol, zolpidem... 

Ritonavir raises desipramine levels and is predicted to also raise the levels of other tricyclic antidepressants. 

A single 100-mg dose of desipramine was given to 14 healthy subjects before and after they took ritonavir 500 mg twice daily for 10 days. The AUC and half-life of desipramine increased nearly 2.5-fold and 2-fold, respectively. The maximum plasma levels were also increased by about... 

BertzRI, Cao G, Cavanaugh JH, Hsu A, Graimeman GR, Leonard JM. Effect of ritonavir ai the phannacckinetics of desipramine. 11 International Conference on AIDS, Vancouver, 1996. AbstoactMo.B.1201. 

Actinomycin-D, amitriptyline, amoxapine, amprenavir, apomorphine atazanavir, citalopram, clomipramine, desipramine, dothiepin, doxepin, efavirenz, fluoxetine, imipramine, indinavir, lopinavir, maprotiline, meropenem, mianserin, nelfinavir, nevirapine, norfluoxetine, nortriptyline, pergolide, paroxetine, procarbazine, ritonavir, sertraline, saquinavir, trimipramine, vincristine, zidovudine... 

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