Simplification, design strategies

The expected significant process simplification and intensification would capitalize on a new industrial paradigm offered by equipments combining reaction and separation in one step. New reactors and overall plant design strategy have to be defined. 

But the capital cost per unit of nameplate energy ( /kW(e)) is likely to increase - perhaps dramatically - by foregoing the economy of scale benefit. The STAR-H2 design strategy attempts to at least partially overcome this by simplification, factory fabrication, short construction interval and more efficient and complete conversion of heat to marketable products. 

In summary, the studies reviewed here use diverse strategies to take advantage of the redox properties of two classes of catechol-quinone compounds present in nature to design new compounds of pharmaceutical interest. In a third class of naturally occurring compounds of complex structure, simplification and removal of the redox-sensitive elements may be key to providing target structures with a novel antiviral character. 

The uniqueness of Groves mechanisms provides an additional simplification to the efficient mechanism design problem when dominant strategy implementations are required. It is sufficient to consider the family of Groves mechanisms, and look for functions hi -) that provide Groves payments that satisfy all of the desired constraints. The Vickrey-Clarke-Groves (VCG) mechanism is an important special case, so named because it reflects the seminal ideas due to Vickrey [100] and Clarke [26]. The VCG mechanism maximizes expected revenue across all strategyproof efficient mechanisms, subject to ex post individual-rationality (IR) constraints. Ex post IR provides ... 

There is no single approach to structure-based design different problems require different kinds of structural information and are likely to be solved in different ways. At the risk of over-simplification, we can describe several common situations and the strategies that have been devetoped to address them (Table 4). This list is ordered according to my opinion of increasing difficulty. 

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