Design of experiment methodology

Design of experiments methodology was used to determine the maximum variability in viscosity which a poly(vinyl chloride)/wood fibre profile extrusion process was able to tolerate. Fourteen critical dimensions, profile bow, shrinkage, Young s modulus, and stress and strain under maximum load were measured. Quadratic models were created from the dimensional measurements, bow, maximum tensile stress, pressure in the die adaptor and the current drawn by the screw drive, and used to establish the tolerances within which the dimensional and physical specifications were simultaneously achieved. 

The influence of selected process parameters on microstructure, composition and mechanical properties of HAp (Figure 5.24), HAp/Ti02 and HAp/PCL coatings was studied using SDEs (statistical design of experiment) methodology. The... 

DGA differential gravimetric analysis DOX design of experiments methodology... 

This work describes an optimization procedure for UP resin synthesis, following tin alktiline-acid process, focusing on the conditions of the condensation step. A design of experiments methodology was employed to optimize the 3 selected factors (number of urea additions, time span between urea additions, and condensation pH), in order to produce particleboards with maximum intemtil bond strength and minimum formaldehyde release. 

An alkaline-acid synthesis process was studied using a design of experiments methodology, in order to optimize the adhesion performance and formaldehyde emission of UE resins. It was concluded that the pH and the time span between consecutive urea additions in the condensation step have a strong influence on the analysed properties. 

Another potential benefit of this approach is to utilize Design Of Experiments methodology to run trials on the simulated process. This will facilitate the study of cause and effect and investigation of dependencies in the process. 

Process analytics have already been utilized in process development, realizing all the benefits of the methodology in the R D environment without facing particnlar regulatory scrutiny as often assumed for commercial manufacturing applications. With the increased use of concepts like design of experiments. 

The methodology of design of experiments has in developed countries made a spedal expansion in solving very complex problems in all fields of human activities. It should be pointed out that an important place in this expansion was the develop-... 

This chapter about design of experiments refers to screening the factors by the significance of their effect on a measured value or response. The researcher has by applying the mentioned methodology ... 

Simplex designs of experiments were first published in 1962 [53], and since then application of this methodology has been constantly growing [31, 54, 10]. Under simplex designing, we understand finding of the optimum of a response function by moving simplex figure on the response surface. Simplex movement is done step by step, whereby in each new step-trial the simplex vertex with the most inconvenient response value is rejected. 

The design of experiments (DOE) is part of response-surface modeling (RSM) methodology. The purpose of experimental designs is to deliver as much information as possible with a minimum of experimental or financial effort. This information is then employed in the construction of sensible models of the objects under investigation. 

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