Design high-throughput methods

Lead explosion and other directed synthesis methods may uncover better compounds, but these may not be the best. Further lead refinement may be necessary, more likely using chemistries that are less amenable to high-throughput methods, to design compounds which will enhance the properties still further. This activity still lies firmly in the domain of conventional medicinal chemistry. 

Method Genomics, traditional biomedical research Animal models, in vitro assays Rational drug design, high throughput screening, combinatorial chemistry Medicinal chemistry In vivo assays, animal models I N D Healthy human volunteers Patients N Patients D A... 

In addition to the methods described above, it may be useful to devise a rapid experimental method for screening solvents and extraction conditions. High-throughput methods are designed to measure a key property and automatically carry out tens or hundreds... 

Polymerization Reactor Design for High-Throughput Methods... 

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