Design-analysis stages

The term design-analysis is used to emphasize the essential, but not dominant, role of analysis in the overall structural design process. Analysis plays no role whatsoever in dress design (with the possible exception of the now-classical analysis of a strapless evening gown). However, engineering design of a structure must involve analysis in the form of mechanistic relationships. Those mechanistic relationships must be used to quantitatively determine how to create the structural capabilities and then to match them to the structural requirements. The dis- 

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A designer, as part of his facility design analysis, should perform a hazards analysis or risk assessment of the various processes which will be conducted within the facility in order to determine what potential thermal dangers or threats exist to personnel and equipment. A hazards analysis or risk assessment will provide for the identification of potential hazards and of the necessary corrective actions/measures to prevent or control the hazard. Early in the design of a facility, the processes and equipment may be conceptual and at this stage, a preliminary hazards analysis can be performed. It is early in the design that a preliminary hazards analysis can be most helpful because its... 

Model validation is a process that involves establishing the predictive power of a model during the study design as well as in the data analysis stages. The predictive power is estimated through simulation that considers distributions of PK, PD, and study-design variables. A robust study design will provide accurate and precise model-parameter estimations that are insensitive to model assumptions. 

Time invested by both the data manager and statistician in designing the structure of the database should also reap rewards at the analysis stage. In addition, a good-quality database is essential if the study is to pass the auditing process. 

A better insight into composition of phases along the separation process is provided by multicomponent process simulation as it can be carried out with commercial process simulating programs, such as ASPEN-h. As usual, the process is separated into theoretical stages. Normally, ASPEN+ provides thermodynamic models and calculates thermodynamic properties such as the distribution coefficients and separation factors. As the accuracy of these results is not sufficient for a design analysis in many cases, distribution coefficients (and if necessary solubilities) can be provided by a user-defined module which uses empirical correlations for these values. 

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