Derris-Lonchocarpus complex

Derris-Lonchocarpus complex (Fabaceae). Gradual modification of oxidation/methylation values of flavonoid profiles suggest dispersal of original... 

Two other important natural products are rotenone and ryanodine. Rotenone (101) (B-71MI10700) is the main insecticidal constituent of certain Derris and Lonchocarpus species, and derris dust is still available as an insecticide. It has been the subject of extensive structural and synthetic studies (B-72MI10704). Ryanodine (102) (B-7lMH070i) is extracted from the wood of Ryania speciosa and has been used in crude extract form as ryania. Despite its extreme complexity it has been totally synthesized (77PAC1329). 

Rotenone, the active ingredient of derris powder, an insecticide prepared from the roots of the leguminous plant Lonchocarpus nicou. It is an inhibitor of complex I (NADH — ubiquinone reduction). The same effect is seen in the presence of amytal (amobarbital), a barbiturate sedative drug, which again inhibits complex I. These two compounds inhibit oxidation of malate, which requires complex I, but not succinate, which reduces ubiquinone directly. The addition of the uncoupler... 

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