Dermatitis berloque

Activity Many F. induce a brown pigmentation in the skin on exposure to sunlight. They are photosensitizing, phototoxic, and can induce allergic dermatitis (Berloque s dermatitis), possibly with severe symptoms such as blister formation. The effect can also arise when, for example, scented toilet waters whose plant components still contain F. are applied to the skin. Use In photochemotherapy for vitiligo, psoriasis, atopic dermatitis, mycosis togoides. Photoactivated F. bind covalently as haptens to proteins as well as pyrimidines of DNA and thus have antimitotic effects. For synthesis, see Lit.. ... 

Zaynoun ST, Aftimos BA, Tenekjian KK, Kurban AK. Berloque dermatitis —a continuing cosmetic problem. Contact Dermatitis 1981 7(2) 111-116. 

Post-inflammatory hyperpigmentation (PIH) (Figure 13.9) and berloque dermatitis usually respond well to TCA they can be treated in the same way as melasma, but have a better prognosis as the original trauma disappears... 

Gruson, L.M., and M.W. Chang. 2002. Berloque dermatitis mimicking child abuse. Arch. Pediatr. Adolesc. Med. 156(11) 1091-1093. 

Use Mainly for the production of perfumes, especially Eau de Colognes and fresh toilet waters. Pressed B. contains up to ca. 1% of the furocoumarin bergap-ten which causes phototoxic reactions (so-called ber-lock or berloque (perfume) dermatitis). Thus mild rectification of B. is recommended before its use in perfume oils, since bergapten remains in the distillation residue. B. is also used in small amounts to aromatize confectionery and bakery products, often in combination with other citrus oils well known is the aromatization of tea ( Earl Grey tea). 

When an individual develops PICD to a fragrance product, it usually appears as a hyperpigmented macule at the site of application of the perfume or cologne. This is the so-called berloque dermatitis [2]. 

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