Dermatan sulfate spectra

FIG. 25.—(A) 13C-N.m.r. Spectrum of Heparin in D20 at Ambient Temperature. (I-Signals are ascribed to a-L-idosyluronic acid residues, and G-signals to 2-amino-2-deoxy-a-D-glucosyl residues chemical shifts are expressed as 8C, relative to external tetramethylsilane.) (B) 13C-N.m.r. Spectrum of Dermatan Sulfate in D20 at 70°. (The horizontal axis is based on 8C, relative to external CS2.)... 

The 220-MHz spectra of chondroitin 4- and 6-sulfate, and of dermatan sulfate, were consistent with structures that had previously been proposed for these compounds, in contrast to the 220-MHz spectrum of keratan sulfate.136 The spectra of chondroitin 6-sulfate, keratan sulfate, and viscous solutions of hyaluronic acid showed broad bands, and, for hyaluronic acid, little structural information could be deduced from its spectrum.136... 

MPS VII Sly Dysostosis multiplex, hepatosplenomegaly wide spectrum of severity, including hydrops fetalis and neonatal form j8-Glucuronidase Dermatan sulfate, heparan sulfate, chondroitin 4-, 6-sulfates... 

The conformation of the L-iduronic acid in dermatan sulfate has been the subject of controversy the proton magnetic resonance spectrum measured at 220 MBs (7) suggested the 04(1) conformation, but optical rotatory dispersion gave conflicting results (18). Recent X-ray diffraction (19) studies seem to favour the C] (L) form, and further evidence in sv port of this hypothesis was obtained by periodate oxidation, altough the possibility could not be excluded that a small non sulfated L-iduronic acid unit had the 04(1) conformation (20). 

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